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Département Biologie Cellulaire

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  • Lundi 26 mars 11:00-12:30 - Ivan BAXTER - Donald Danforth Plant Sciences Center, St Louis (MO) USA

    Can We Use Elemental Profiles to Understand How Plants Adapt to Their Environments ?

    Résumé : Contact : Sebastien.THOMINE

    Lieu : Auditorium I2BC - Bât. 21, Campus de Gif-sur-Yvette

  • Vendredi 30 mars 11:00-12:00 - Manuel THERY - Institut Universitaire d'Hematologie, Hopital Saint Louis, Paris, invité par A.M. Tassin

    Making sense of symmetry breaks

    Résumé : In this presentation I will discuss the role of friction in and on actin and microtubule networks. I will describe few examples showing that friction in the networks tend to maintain the symmetry whereas friction on the networks tend to break it. I will discuss how these geometrical rules propagate to the overall cell polarity via actin-microtubule crosstalk.

    Lieu : Bibliothèque - bâtiment 34 - Campus de Gif-sur-yvette

  • Vendredi 6 avril 11:00-12:30 - Zofia CHRZANOWSKA LIGHTOWLERS - Newcastle University, invitée par N. Bonnefoy

    Human mitochondrial translation : what makes the proteins and how are they escorted to their final destination ?

    Résumé : The ribosome is the molecular machinery that synthesises proteins from template mRNA. Many features are common to ribosomes be they bacterial 70S particles, or 80S monosomes present in the eukaryotic cytosol. Although mitoribosomes have retained certain elements of the bacterial ribosome, both protein and rRNA, they have also diverged from the template in a number of ways. This is particularly true for human mitochondria that have been revealed by cryo-EM to have integrated unexpected components. These similarities, differences and some of the idiosyncrasies of the human mitoribosome will be described along with an example of the plasticity in the system, which is seen when things go wrong.

    Lieu : salle des séminaires - bâtiment 26 - campus de Gif-sur-Yvette

  • Vendredi 6 avril 11:00-12:30 - Robert LIGHTOWLERS - Newcastle University, invité par N. Bonnefoy

    Human mitochondrial translation : what makes the proteins and how are they escorted to their final destination ?

    Résumé : The function of human mitochondrial insertase Oxa1L, the human homolog of yeast Oxa1 (first described by members of CGM in Gif-Sur-Yvette) has remained contentious since its identification over 20 years ago. Recently, we have identified a patient with a biallelic mutation in OXA1L that causes a mitochondrial disease due to a combined oxidative phosphorylation deficiency. Previous experiments with shRNA depletion of human Oxa1L reported a defect in complexes I and V but spared any involvement in cytochrome c oxidase assembly (COX ; complex IV), a surprising result as Oxa1L had been expected to be essential for the insertion of all mtDNA encoded components. Patient muscle and fibroblasts show a decrease in Oxa1L but also a depletion of complex IV and V with a relative sparing of complex I, a phenotype rescued by expression of wild type Oxa1L. Targeted depletion of OXA1L in Drosophila melanogaster caused defects in the assembly of complexes I, IV and V. Targeted disruption of Oxa1L in human HEK293T cells required the co-expression of exogenous Oxa1L to prevent lethality, but the controlled loss of Oxa1L resulted in a substantial loss of complexes I, III, IV and V. Neuropathological experiments from the Oxa1L-deficient patient, however, indicate an isolated complex I deficiency. Taken together, whilst our data verify the pathogenicity of mutations in Oxa1L and demonstrate it is required for the assembly of multiple OXPHOS complexes, we find striking tissue and cell specific variation, perhaps implying the existence of other tissue-specific insertases involved in mitochondrial protein synthesis.

    Lieu : salle des séminaires - bâtiment 26 - campus de Gif-sur-Yvette

  • Vendredi 20 avril 11:00-12:00 - Eelco VAN ANKEN - San Raffaele Scientific Institute, Università Vita-Salute San Raffaele, Milan, Italy, invité par B. D'Autréaux

    How cells evaluate whether homeostatic readjustment in the endoplasmic reticulum is a success or failure

    Lieu : Bibliothèque - bâtiment 34 - Campus de Gif-sur-Yvette

  • Vendredi 4 mai 11:00-12:00 - Alexis MAIZEL - Heidelberg, Allemagne, invité par Grégory Vert

    Séminaire Alexis MAIZEL

    Lieu : Auditorium - bâtiment 21 - campus de Gif-sur-Yvette

  • Vendredi 15 juin 11:00-12:30 - Nicolas OLIVIER - Ecole Polytechnique, invité par A.M. Tassin

    Séminaire Nicolas OLIVIER

    Lieu : Bibliothèque - bâtiment 34 - campus de Gif-sur-Yvette

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