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Accueil > Séminaires

Département Biologie des Génomes

par Clubs génome, EQYY - publié le , mis à jour le


  • Mardi 20 février 11:00-12:30 - Ali Hamiche - IGBMC-Illkirch

    Towards a comprehensive view of the epigenetic landscape

    Résumé : Histone variants are essential epigenetic players implicated in key nuclear events. However, their role in transcription regulation and genome organization is not clear and much remains to be done to understand their function in these processes. A key question for understanding their functional and structural involvement in all these roles is whether their location through chromatin is random or not, and if not, how are the specific sites of deposition determined and regulated ? The purpose of this presentation is to provide a comprehensive view about the genome-wide pattern of histone variants distribution in relation to DNA methylation and to their potential role in promoter architecture organization and transcription regulation.

    Lieu : salle de conférence du Bât. 144 - Bât. 144
    Campus CEA/Saclay

  • Vendredi 16 mars 11:00-12:00 - Damien Coudreuse - Institut de Génetique & Développement de Rennes

    Shaping cell proliferation : cell cycle progression and CDK activity dynamics

    Résumé : Cell cycle progression is central to cell proliferation in normal and pathological contexts. Despite the complexity of the eukaryotic cell cyclecontrol, we previously showed that the core engine of cell proliferation relies on the simple oscillation of a single qualitative cyclin-dependent kinase (CDK) activity between a low (S phase) and high (M phase) threshold. While this model explains the main cell cycle transitions, the importance of the temporal profile of CDK activity remains unknown. In other words, do the precise dynamics in CDK function throughout the cell cycle play a role in the integrity of cell proliferation, as was suggested by mathematical models ? Or is the two-threshold model sufficient to understand how eukaryotic cells organise their cell cycle ? Using a synthetic approach to cell cycle control in fission yeast coupled with high resolution microscopy and microfluidic technologies, our recent work reveals how CDK activity dynamics shape cell cycle progression and act as a noise filter.
    Contact : Julie SOUTOURINA <julie.soutourina>

    Lieu : Auditorium - bâtiment 21 - Campus CNRS de Gif-sur-Yvette

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