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Département Biologie des Génomes

par Clubs génome, EQYY - publié le , mis à jour le


  • Vendredi 16 mars 11:00-12:00 - Damien Coudreuse - Institut de Génetique & Développement de Rennes

    Shaping cell proliferation : cell cycle progression and CDK activity dynamics

    Résumé : Cell cycle progression is central to cell proliferation in normal and pathological contexts. Despite the complexity of the eukaryotic cell cyclecontrol, we previously showed that the core engine of cell proliferation relies on the simple oscillation of a single qualitative cyclin-dependent kinase (CDK) activity between a low (S phase) and high (M phase) threshold. While this model explains the main cell cycle transitions, the importance of the temporal profile of CDK activity remains unknown. In other words, do the precise dynamics in CDK function throughout the cell cycle play a role in the integrity of cell proliferation, as was suggested by mathematical models ? Or is the two-threshold model sufficient to understand how eukaryotic cells organise their cell cycle ? Using a synthetic approach to cell cycle control in fission yeast coupled with high resolution microscopy and microfluidic technologies, our recent work reveals how CDK activity dynamics shape cell cycle progression and act as a noise filter.
    Contact : Julie SOUTOURINA <julie.soutourina>

    Lieu : Auditorium - bâtiment 21 - Campus CNRS de Gif-sur-Yvette

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