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Genome Biology Department

by EQYY - published on , updated on


  • Friday 26 January 14:00-15:00 - Yaser Hashem - Institut Européen de Chimie et de Biologie, INSERM

    Protein translation initiation in eukaryotes: A jigsaw puzzle that has barely started yielding its picture

    Résumé : Translation initiation in eukaryotes is a highly regulated and rate-limiting process. It results in the assembly and disassembly of numerous transient and intermediate complexes involving over a dozen initiation factors (eIFs). This process culminates in the accommodation of a start-codon marking the beginning of an open reading frame (ORF) at the appropriate ribosomal site. Here, we present a model of the eukaryotic translation initiation process based on recent structures mainly derived by cryo-EM. In addition, we present new results that highlight some of the structural implications of the kozak sequence on the initiation complex formation. Finally we present some of the species-specific aspects of translation initiation in Kinetoplastids, a group of pathogenic eukaryotic organisms.
    Contact : Carmela Giglione <carmela.giglione>

    Lieu : Bibliothèque - bâtiment 34 - Campus CNRS de Gif-sur-Yvette

  • Tuesday 20 February 11:00-12:30 - Ali Hamiche - IGBMC-Illkirch

    Towards a comprehensive view of the epigenetic landscape

    Résumé : Histone variants are essential epigenetic players implicated in key nuclear events. However, their role in transcription regulation and genome organization is not clear and much remains to be done to understand their function in these processes. A key question for understanding their functional and structural involvement in all these roles is whether their location through chromatin is random or not, and if not, how are the specific sites of deposition determined and regulated? The purpose of this presentation is to provide a comprehensive view about the genome-wide pattern of histone variants distribution in relation to DNA methylation and to their potential role in promoter architecture organization and transcription regulation.

    Lieu : salle de conférence du Bât. 144 - Bât. 144
    Campus CEA/Saclay

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