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Accueil > Séminaires

Département Virologie

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Agenda

  • Vendredi 8 décembre 11:00-12:30 - Pierre-Yves Lozach - Université d’Heidelberg

    Early arbovirus-host cell interactions : from virus transmission to cell entry and pathogenesis

    Résumé : During natural transmission, arboviruses are introduced into vertebrate host skin through arthropod bites, and the life cycle of viruses switch from the cell biology of arthropod vectors to that of vertebrate hosts. Indeed, the cell biology in vertebrate hosts is different from that in arthropod vectors, the consequence being that arbovirus particles can change some components and the composition of their lipid and glycan coats during host switch. However it remains unclear whether host alternation is important at the molecular level for the early steps of infection and virus entry into the first-target host cells as well as the subsequent steps leading to the pathogenesis. Within this talk, these issues will be addressed based on the analysis of the phleboviruses Rift Valley fever and Uukuniemi in arthropod vector and mammalian host cells by state-of-the-art fluorescence-based techniques in fixed and living cells.

    Lieu : Salle de séminaires bâtiment 14C - Bât. 14C
    Campus Gif-sur-Yvette


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