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Discovery of a novel DNA repair system

This work is published in Science and was performed by Gilbert Richarme and his collaborators from CNRS, CEA, universities Paris-Diderot, Paris-Descartes, Paris-Sud1 and from the Harvard Medical School, and the Lebanese American University .

Philippe Bouloc, “Signaling and Regulatory Networks in Bacteria“ Group Leader and one of this authors explains :
“Bacterial systems are invaluable for discovering the molecular bases of living organisms. Our new findings use the model bacterium Escherichia coli to understand the function of a human protein called DJ1, which is implicated in some cases of Parkinson’s disease. This protein has three functional homologues in E. coli. Glyoxals are harmful byproducts of sugar metabolism that damage cellular components. The team of Prof. Gilbert Richarme had previously shown that DJ1 and its bacterial homologues are deglycases that repair proteins altered by glyoxals. The new work in which we collaborated shows that DJ1 and its bacterial counterparts repair guanines damaged by glycation, whether they are free or incorporated in DNA. Deficient bacteria with no deglycases have an increased mutation rate. This discovery highlights a system conserved from bacteria to humans that preserves DNA integrity.”



Download the French press release (pdf) or find more information on the CNRS Website
Find the publication :
Guanine glycation repair by DJ-1/Park7 and its bacterial homologs.
Gilbert Richarme, Cailing Liu, Mouadh Mihoub, Jad Abdallah, Thibaut Leger, Nicolas Joly, Jean-Claude Liebart, Ula Jurkunas, Marc Nadal, Philippe Bouloc, Julien Dairou, Aazdine Lamouri, Science, 08 jun 2017.



1 This work involves researchers from Institut Jacques Monod (Université Paris Diderot / CNRS), l’Institut de biologie intégrative de la cellule (CNRS/CEA/Université Paris Sud), Laboratoire de chimie et biochimie pharmacologiques et toxicologiques (CNRS/Université Paris Descartes) and laboratoire Interfaces, traitements, organisation et dynamique des systèmes (CNRS/Université Paris Diderot)

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