Plateforme de Résonance Paramagnétique Électronique (RPE)
EPR is the only method for the direct detection of paramagnetic species. Electron paramagnetic resonance (EPR) spectroscopy applications span across a wide range of areas from quality control to molecular research in fields such as material research, structural biology and quantum physics. EPR experiments have provided invaluable information pertaining to metalloprotein structures and to the structures and processes in photosynthesis for example.
EPR equipment located at the I2BC is a unique platform for applications in Life Sciences. Local research projects making a heavy use of EPR are mainly centered around enzymatic systems associated with oxidative stress or photosynthesis :
Catalytic mechanism of metalloproteins with iron or manganese : photosynthetic complexes, NO-synthase, cytochrome P450, mono and bifunctional peroxidases, superoxide dismutase
Biomimetic chemical complexes
Metal- peptide systems involved in neurodegeneration
Oxidative stress in Plants
Protein radicals involved in enzyme catalysis