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  • Lundi 2 juin 2014 14:00-15:30 - Taekjip Ha - Université de physique de l'Illinois

    Surprising physics of DNA and its implication in gene regulation

    Résumé : Summary : Using advanced single molecule measurements techniques and all atom computational simulations, we discovered two interesting physical properties of DNA. First, DNA sequence and modifications have profound influence on DNA flexibility which in turn determines the asymmetry in mechanical stability of nucleosomes and the accessibility of nucleosomal DNA. Second, DNA sequence and modifications strongly influence association between double stranded DNA molecules without Watson-Crick basepairing, thereby affecting chromosomal organizations.

    Lieu : Bâtiment 21, auditorium - CNRS de Gif sur Yvette

  • Vendredi 6 juin 2014 14:00-15:30 - Yves Barral - Institut de biochimie de l'ETH ZURICH

    Genomic immunity : How do eukaryotes protect themselves against the propagation of foreign DNA molecules ?

    Lieu : Bâtiment 21, auditorium - CNRS de Gif sur Yvette

  • Jeudi 12 juin 2014 10:00-11:30 - Niko Hildebrandt

    Luminescence and FRET : Time-resolved spectroscopy and imaging for sensitive multiplexed biosensing

    Résumé : Summary :
    "Applications based on Förster Resonance Energy Transfer (FRET) play an important role for the determination of concentrations and distances within nanometer-scale systems in vitro and in vivo in many fields of the life sciences. Using time-resolved optical spectroscopy and microscopy for the analysis of FRET systems offers several advantages concerning sensitivity and specificity. Two extraordinary materials concerning time-resolved FRET are luminescent lanthanide complexes (LLCs) and semiconductor quantum dots (QDs). Both are frequently used as FRET donors in combination with organic dyes, fluorescent proteins and other fluorophores. However, their combination as LLC-QD donor-acceptor pair gives access to unique optical properties, which make this FRET-pair an incredible tool for highly sensitive multiplexed diagnostics.
    The presentation will start with an introduction to FRET, lanthanide complexes and quantum dots and their possible applications. Then it will focus on recent research results concerning FRET for ultrasensitive multiplexed biosensing applications such as homogeneous immunoassays, microRNA detection, enzyme kinetics, molecular rulers, epithelial-mesenchymal transition, molecular logic gates, and crossing of the blood-brain barrier."

    Lieu : Salle de conférence George Prevost ISV/CGM - Campus de Gif sur Yvette

  • Lundi 1er septembre 2014 14:30-15:30 - Marina Rodnina

    Co-translational protein folding on the ribosome

    Résumé : Marina Rodnina : "Co-translational protein folding on the ribosome

    Lieu : Auditorium bâtiment 21 - Campus CNRS de Gif/Yvette

  • Lundi 1er septembre 2014 15:30-16:30 - Wolfgang Wintermeyer

    Interplay between protein biogenesis factors at the peptide exit of the ribosome

    Lieu : Auditorium bâtiment 21 - Campus CNRS de Gif/Yvette

  • Vendredi 5 septembre 2014 10:30-12:30 - Franck Perez

    Rushing to study Golgi-dependent protein secretion in mammalian cells

    Lieu : Auditorium bâtiment 21 - Campus CNRS de Gif/Yvette

  • Mardi 30 septembre 2014 11:00-13:00 - Annemarie Wehenkel

    Understanding the molecular mechanisms of tubulin heterogeneity

    Lieu : Auditorium bâtiment 21 - Campus CNRS de Gif/Yvette

  • Mardi 7 octobre 2014 14:00-15:00 - Xavier Darzacq

    Dissecting transcription regulation using single molecule imaging

    Lieu : Auditorium bâtiment 21 - Campus CNRS de Gif/Yvette

  • Vendredi 21 novembre 2014 11:00-12:00 - Cristina Risco - Centro Nacional de Biotecnología, Madrid

    Studying viral infections and cell architecture with new imaging techniques

    Résumé : Replication and assembly of many RNA viruses take place in specific intracellular compartments known as ‘virus factories’, ‘viral inclusions’ or ‘viroplasms’. Our knowledge of the biogenesis and architecture of these unique structures has increased considerably in the last few years, due to technical advances in cellular, molecular and structural biology. Early in infection, viral polymerases and cofactors interact with cell membranes, where they build functional replication complexes (RC) and replication organelles. These structures recruit viral and cell factors to build a platform on which viral replication and morphogenesis are spatially connected. Factories are very dynamic, as their structure changes over time. A number of imaging technologies are helping us to understand how factories are built and work. 3D imaging shows the complex organization of virus factories, in particular the new interactions built between virus-induced membranous scaffolds, cytoskeleton and recruited organelles. A summary of recent findings on the structure of factories will be presented, including 3D reconstructions of serial sections, electron tomography and molecular mapping with antibodies and with the new clonable tag for electron microscopy based on the small metal-binding protein metallothionein (MT). Study of the intracellular distribution of MT-tagged viral replicase proteins revealed virus-induced structures not previously observed. Designing strategies to combine functional and mechanistic studies with 3D imaging will be necessary to understand the meaning of the structures built by viruses in the infected cell.Retour ligne automatique
    Fernández de Castro, I., Volonte, l., Risco, C. Virus factories : biogenesis and structural design. Cell Microbiol, 2013. 15 : 24-34.
    Barajas, D., Fernández de Castro, I., Pogany, J., Risco, C., & Nagy, P.D. Noncanonical role for the host Vps4 AAA+ ATPase ESCRT protein in the formation of Tomato bushy stunt virus replicase. PLoS Pathog, 2014. 10(4) : e1004087.
    Fernández de Castro, I., Zamora, P.F., Ooms, L., Fernández, J.J., Lai, C.M.-H., Mainou, B.A., Dermody, T.S., & Risco, C. Reovirus forms neoorganelles for progeny assembly within reorganized cell membranes. mBio, 2014. 5:e00931-13.
    Risco, C., Fernández de Castro, I., Sanz-Sánchez, L., Narayan, K., Grandinetti, G., Subramaniam, S. 3D imaging of viral infections. Annu Rev Virol, 2014. 1:453-473.
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    Invité par Yves Gaudin (Virologie)

    Lieu : Amphitéâtre Bâtiment 21, Campus Gif

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  • Vendredi 25 septembre 2015 - I2BC -MICALIS – VIM

    Première rencontre I2BC -MICALIS – VIM

    Lieu : Auditorium Bâtiment 21 - Campus CNRS
    Avenue de la terrasse
    Gif Sur Yvette

  • Du 5 octobre 2016 14:00 au 7 octobre 2016 13:00 -

    Journées Scientiques de l’I2BC

    Résumé : Nous recevons Jörg Vogel, Eriko Takano, Harald Stenmark et Jordan Raff.
    L’inscription est obligatoire et la clôture des inscriptions aura lieu le 18 septembre sur le site du colloque (lien)
    Il est encore possible de proposer des posters en suivant les recommandations (pdf)
    Nous espérons vous voir nombreux !
    Le comité d’organisation

    Lieu : Auditorium - Bâtiment 21, Campus de Gif

  • Mercredi 18 janvier 09:00-17:00 -

    BIG/3D_CHROME meeting

    Résumé : Click to download the program

    09:00 - 09:15 Welcome (F Boccard)
    Research projects supported by the BIG Lidex
    09:15 - 09:35 Tamara Basta-Leberre (BIG project coordinator, I2BC)
    Structure, mechanism and evolution of the universal tRNA
    threonylcarbamoylation systems

    09:35 - 09:55 Maria Costa (BIG project coordinator, I2BC)
    Bacterial group II introns targeting translational punctuation signals :
    mechanisms and implications

    09:55 - 10:15 Daniel Gautheret (BIG project coordinator, I2BC)
    The bizarre transcriptome of RNA processing mutants : lessons from AGO2 and

    10 : 15 - 10:35 Carmela Giglione (BIG project coordinator, I2BC)
    Proteogenomic analysis to monitor N-terminal cotranslational protein
    maturation in vivo

    10:35 - 10:55 Coffee break
    10:55 - 11:20 Yoshiharu Yamaichi (BIG project coordinator, I2BC) and Ipek Altinoglu (BIG PhD student, Yamaichi lab, I2BC)
    Organization of bacterial cells
    11:20 - 11:35 Florian Carlier (BIG PhD student, Malagnac lab, I2BC)
    Are RIP and heterochromatin involved in Podospora anserina sexual
    development ?

    11:35 - 11:50 Charbel Souaid (BIG PhD student, Noordermeer lab, I2BC)
    Identification and functional characterization of constitutive gene-enhancer loops
    in mouse embryonic stem cells

    11:50 - 12:05 Ganna Kychygina (BIG PhD student, Crabbé lab, I2BC)
    Connection between nuclear envelope dysfunction and DNA damage response at

    12:05 - 13:30 lunch
    Technological projects supported by BIG - connection with 3D_CHROME
    13:30 - 13:50 Dominique Fourmy (BIG project coordinator, I2BC)
    Fluorescence microscopy : from single molecule dynamics to live cell imaging
    13:50 - 14:10 Romain Le Bars (Imagerie Gif platform, I2BC)
    PALM & dSTORM : from single molecule localization to super-resolution imaging
    and much more

    14:10 - 14:30 Laure Crabbé (I2BC, 3D_CHROME)
    Super-resolution microscopy to follow human telomeres dynamics in live cells
    14:30 - 15:00 Claude Thermes and Daan Noordermeer (I2BC, 3D_CHROME)
    New genomics approaches incorporating Nanopore Sequencing at the I2BC
    15:00 - 15:20 Valérie Gaudin (IJPB, 3D_CHROME)
    Spatial modeling of nuclear organization in plants
    15:20 - 15:45 Coffee break
    15:45 - 17:00 3D_CHROME business meeting (chair : M Bétermier)
    Click to download the program

    Lieu : Auditorium - Building 21, CNRS campus, Gif-sur-Yvette

  • Lundi 30 janvier 09:00-18:00 -

    Recombination and Epigenetics : Symposium in memory of Jean-Luc Rossignol

    Résumé : Un colloque est organisé le 30 janvier 2017 en hommage au Pr Jean Luc Rossignol à l’initiative de la Société Française de Génétique. Vous trouverez joint l’affiche, les modalités pratiques et le programme de cette journée. Ce colloque est gratuit mais il est recommandé de s’inscrire.
    - site d’inscription
    - Programme
    - Affiche

    Lieu : Amphithéâtre Buffon, Université Paris-Diderot - 15 rue Hélène Brion 75013 Paris
    Accès : RER C, Métro ligne 14, Bus n°62, 64, 89 et 325 :arrêt Bibliothèque François Mitterrand

  • Vendredi 8 décembre 09:00-17:00 -

    YOUR-Carreer day

    Lieu : Auditorium - Bâtiment 21, campus de Gif

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