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Accueil > Départements > Biochimie, Biophysique et Biologie Structurale > Benoit GIGANT & Julie MENETREY : Biochimie Structurale des Microtubules, des Kinésines et de leurs Cargos

Galerie d’images

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Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin.

PubMed : Wang W, Cantos-Fernandes S, Lv Y, Kuerban H, Ahmad S, Wang C, Gigant B. (2017) Nat Comm. 8:70.

PDB : 5MIO


The structural switch of nucleotide-free kinesin.

PubMed : Cao L, Cantos-Fernandes S, Gigant B. (2017) Sci Rep. 7:42558.


Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.

PubMed : Ahmad S, Pecqueur L, Dreier B, Hamdane D, Aumont-Nicaise M, Plückthun A, Knossow M, Gigant B. (2016) Sci Rep. 6:28922.



Structure of a truncated form of the Leucine Zipper II of JIP3 reveals an unexpected anti-parallel coiled-coil arrangement.

PubMed : Llinas, P, Chenon, M, Nguyen, TQ, Moreira, C, de Régibus, A, Coquard, A, Ramos, MJ, Guerois, R, Fernandes, PA, Ménétrey, J (2016) Acta Cryst F72.

PDB : 4PXJ



Apo-kinesin bound to tubulin.

PubMed : Cao L, Wang W, Jiang Q, Wang C, Knossow M, Gigant B. The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement. (2014) Nat Commun. 5:5364.

PDB : 4LNU



Structure of the tubulin-interacting protein CopN from Chlamydia pneumoniae.

PubMed : Nawrotek A, Guimarães BG, Velours C, Subtil A, Knossow M, Gigant B. Biochemical and structural insights into microtubule perturbation by CopN from Chlamydia pneumoniae. (2014) J Biol Chem. 289(36):25199-210.

PDB : 4P3Z



Structure of a stathmin-like domain (magenta) that binds 4 αβ-tubulin molecules.

PubMed : Mignot I, Pecqueur L, Dorléans A, Karuppasamy M, Ravelli RB, Dreier B, Plückthun A, Knossow M, Gigant B. Design and characterization of modular scaffolds for tubulin assembly. (2012) J Biol Chem. 287(37):31085-94.

PDB : 4F61



A tubulin:DARPin complex.

PubMed : Pecqueur L, Duellberg C, Dreier B, Jiang Q, Wang C, Plückthun A, Surrey T, Gigant B, Knossow M. A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end. (2012) Proc Natl Acad Sci U S A. 109(30):12011-6.

PDB : 4DRX



A tubulin:stathmin-like domain complex with bound colchicine (yellow) and ustiloxin D (green).

PubMed : Ranaivoson FM, Gigant B, Berritt S, Joullié M, Knossow M. Structural plasticity of tubulin assembly probed by vinca-domain ligands. (2012) Acta Crystallogr D Biol Crystallogr. 68(Pt 8):927-34.

PDB : 3UT5



The structural switch of tubulin upon GTP binding.

PubMed : Nawrotek A, Knossow M, Gigant B. The determinants that govern microtubule assembly from the atomic structure of GTP-tubulin. (2011) J Mol Biol. 412(1):35-42.

PDB : 3RYF and 3RYI



The structural basis of Arf effector specificity : the crystal structure of ARF6 in a complex with JIP4.

PubMed : Isabet, T, Montagnac, G, Regazzoni, K, Khadali, El, F, Franco, M, Chavrier, P, Houdusse, A, Ménétrey, J (2009). Embo J 28, 2835–2845.

PDB : 2W83

 


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