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Accueil > Départements > Biologie Cellulaire > Sébastien THOMINE : Approches Intégratives du Transport des Ions

Mechano-sensitive channels

Project Leader : Jean-Marie FRACHISSE

Mechano-sensitive channels : transducers of mechanical forces.

Plants, like animals, are facing multiple mechanical constraints generated both in their tissues and by the surrounding environments. To sense the forces, thus generated, plants have developed different “mechanosensors” among them the fascinating Mechanosensitive channel.
Since 2008 we work on the role of mechanosensitive channels in plant mechanopercetion. We were the first, in collaboration with E. Haswell (Washington University, MO) to show that Mechanosensitive channel Small conductance-Like (MSL) proteins provide a mechanosensitive channel activity at the plasma membrane of Arabidopsis.

Ongoing projects :

Mechanosensitive channels, sensors of mechanical oscillations in Arabidopsis thaliana

This project initiated in the frame of the SENZO ANR project (2009-2014) aims to test the hypothesis that MSL channels may constitute “oscillation sensor” for the plant. Three levels of approach are investigated :
1- The MSL channel with the characterization of the activity in response to frequency mechanical solicitations (patch clamp)
2-The tissue level with the study of “mechano sensitive” genes expression as a function of stress frequency loaded to the plant
3-The whole plant level with the dynamic behaviour of plant, affected in MSL expression, under vibration stimulation

MSL channels, mechanosensitive sensors of the legume plant’s root hair Medicago truncatula

This project, initiated in the frame of the CAROLS ANR program (2012-2015), aim to obtain, through functional and modeling approaches, a holistic view of the involvement of the Mechanosensitive channels–Small conductance Like family (MSL) in root hair plasma membrane during the first steps of the symbiotic interaction between the model Legume Medicago truncatula and its microsymbiont Sinorhizobium meliloti.

Outcome of our research : Plant Vibration Phenotyping

Because vibrational measurements are, non-invasive, easy to performed and provide a lot of information on the mechanics of the plant, Vibrational Signature is an excellent candidate to be included as a phenotypic trait of the plant. In collaboration with E. DeLangre ( LadHyX, Polytechnique) and B. Moulia (PIAF,INRA) we develop a novel application in the field of plant phenotyping (VIBROPENE-1 funded by CNRS, VIBROPHENE-2 funded by IDEX Paris-Saclay)

Call for application :
The lab welcomes applications from motivated scientists who are willing to apply for PhD or postdoc fellowships.
Master 2017-2018 : M2 Research practicum on mechanosensitive channels
Contact : jean-marie.frachisse

Contact Info:Let’s meet@
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links with our partners
LadhyX mechanic-living-systems
PIAF Clermont-Ferrand
Plant mechanotransduction Haswell-lab, St louis, USA

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