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Accueil > Départements > Biologie des Génomes > Laure CRABBE : Telomeres et organisation du génome

Les publications

2016


  • B. Pardo, L. Crabbé, et P. Pasero, « Signaling Pathways of Replication Stress in Yeast », FEMS yeast research, 2016.
    Résumé : Eukaryotic cells activate the S-phase checkpoint in response to a variety of events affecting the progression of replication forks, collectively referred to as replication stress. This signaling pathway is divided in two branches: the DNA damage checkpoint (DDC) and the DNA replication checkpoint (DRC). Both pathways are activated by the sensor kinase Mec1 and converge on the effector kinase Rad53. However, the DDC operates throughout the cell cycle and depends on the checkpoint mediator Rad9 to activate Rad53, whereas the DRC is specific to S phase and is mediated by Mrc1 and other fork components to signal replication impediments. In this review, we summarize current knowledge on these two pathways, with a focus on the budding yeast Saccharomyces cerevisiae, in which many important aspects of the replication stress response were discovered. We also discuss the differences and similarities between DDC and DRC and speculate on how these pathways cooperate to ensure the complete and faithful duplication of the yeast genome under various replication stress conditions.
    Mots-clés : DBG, TENOR.
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Publications majeures avant 2015

- Cesare A. J., Hayashi, M.T., Crabbe L., Karlseder J. (2013) The telomere deprotection is functionally distinct from the genomic DNA damage response. Molecular Cell 25(2):141-55

- Crabbe L., Cesare A. J., Kasuboski J. M., Fitzpatrick J. A. J., Karlseder J. (2012) Human telomeres are tethered to the nuclear periphery during post-mitotic nuclear assembly. Cell Reports 2(6):1521-9

- Crabbe L., Karlseder J. (2010). Mammalian Rap1 widens its impact. Nature Cell Biology 12(8):733-5

- Crabbe L., Jauch A., Naeger C.M., Holtgreve-Grez H., Karlseder J. (2007). Telomere dysfunction as a cause of genomic instability in Werner Syndrome. Proc Natl Acad Sci USA 104(7):2205-10

- Crabbe L., Verdun R.E., Haggblom C.I., Karlseder J. (2004). Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306(5703):1951-3.

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