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Presentation of the Genome Biology Department

Leader : Mireille BETERMIER


Research performed in the department aims to understand the mechanisms responsible for the dynamics and stability of genomes, on the one hand, and those involved in the regulation of gene expression from the initiation of transcription to co-translational modification of proteins, on the other hand. Bioinformatics is a strong transverse axis of the department, indispensable for any functional genomics study based on DNA sequencing or proteomics. The experimental approaches used range from molecular genetics to genomics and rely on the increasing use of advanced cell imaging techniques. The teams in the department rely on a variety of models ranging from prokaryotes (archeae and bacteria) to unicellular (yeasts, fungi, paramecium) and multi-cellular eukaryotes (drosophila, xenopus, mice, human cells) to investigate the biological questions that are of interest.
A number of biological questions are transverse to the department and are of interest to many teams. The three-dimensional organization of genomes and its impact on DNA transactions is one of them. This theme is supported by a program supported by the Université Paris-Saclay, 3D_Chrome. The department teams have recently made significant advances in understanding the impact of chromatin organization and its effect on gene expression and genome stability. Chromatin obviously plays a key role in these processes and the deciphering the mechanisms involved is essential to the understanding of DNA processes. RNAs are involved in the regulation of gene expression, have catalytic functions and play roles in the structure of chromatin. One of the department’s main themes is the study of the regulatory functions of RNAs.

J. ACKER & O. LEFEBVRE : Nuclear Regulation and Stress
F.X. BARRE : Evolution and Maintenance of Circular Chromosome
M. BETERMIER : Programmed genome rearrangements
F. BOCCARD : Conformation and segregation of the bacterial chromosome
P. BOULOC : Signaling and Regulatory Networks in Bacteria
S. CHEDIN & L. KURAS : Physiology and Pathogenicity of Stresses
F. CONFALONIERI : Bacteria and Archae radioresistance
M. COSTA : Structure, Function and Evolution of Bacterial Retrotransposons
L. CRABBE : Telomeres and genome organization
R. DEBUCHY & F. MALAGNAC : Sexual Development and Meiosis in Fungi
N. FIGUEROA : Gene Regulation in Salmonella and its Phages
D. FOURMY : Structure and dynamics of RNA
D. GAUTHERET : RNA Sequence, Structure & Function
M. GERARD : Epigenomic of mamalian
C. GIGLIONE : Protein Maturation, Cell Fate & Therapeuthics
O. LESPINET : Molecular BioInformatic
C. MANN  : Senescence and Genome Stability
K. MARHEINEKE : DNA replication dynamics in higher eukaryotes
B. MICHEL : Bacterial DNA Stability
M. MIRANDE : Supramolecular assemblies and Traduction
O. NAMY : Genomic, Structure and Translation
D. NOORDERMEER : Chromatin Dynamics
M. ROUGEMAILLE : RNA-binding proteins in gene expression and cell differentiation
J. SOUTOURINA : Genome transcriptional regulation
L. SPERLING : Genome Analysis
Y. YAMAICHI : Integrity of genome and polarity in bacteria

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