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Séminaire

  • Génomes

    • Vendredi 1er décembre 2017 11:00-12:00 - Pierre Amato - CNRS, UMR 6296, ICCF (Institut de Chimie de Clermont-Ferrand), Université Clermont Auvergne, France

      Structure and functioning of cloud microbiota

      Résumé : The atmosphere carries microorganisms and connects distant ecosystems. In addition of the underlying epidemiological issues associated with the presence of living microorganisms in the air, it was shown recently that they can contribute to atmospheric physico-chemical processes. Clouds are thus now considered in some aspects as habitats for microorganisms, albeit temporary by essence. Our first culture-based studies led on cloud microflora recovered from the atmospheric observatory at the puy de Dôme mountain summit (1465 m asl.), in the early 2000’s, revealed a high diversity in the microbial community, dominated by a few genera of bacteria and fungi. The advent of new DNA amplification methods (MDA), associated with next generation sequencing tools allows clarifying our vision of cloud biodiversity and its functioning, while overcoming the difficulties raised by the low biomass in these environments ( 104 cells m-3). Thereby, cloud water metagenomes, metatranscriptomes and amplicons libraries (16S and 18S rRNA genes) were investigated. The results showed a high taxonomic diversity in both prokaryotes and eukaryotes, but a very uneven distribution dominated by a few abundant OTUs. The large domination of Proteobacteria was confirmed, and the presence of noticeable groups such as viruses, Cyanobacteria and Archaea was observed. The active biodiversity was largely related to some groups of bacteria, notably Alpha- and Gamma-Proteobacteria. Metatranscriptomes showed a large overrepresentation of functions related to metabolic regulation, genome reorganization, access to substrates and defense against oxidants. These new pictures of cloud microbial communities indicate that these are environments open to numerous taxa, but where only a few can maintain and thus successfully disperse. They must rapidly adjust their functioning for surviving in these dynamic environments, suggesting that atmospheric transport probably operates strong selection on the microorganisms of outdoor surfaces, and thus drives to some extent microbial evolution.
      Contact : Jean-Luc Ferat <jean-luc.ferat i2bc.paris-saclay.fr>

      Lieu : Bibliothèque- bâtiment 34 - Campus CNRS de Gif-sur-Yvette

      Article

    • Vendredi 8 décembre 2017 11:00-12:00 - Olivier Espeli - Collège de France

      Dealing with environmental stresses through bacterial cell cycle contortions

      Résumé : Abstract not available
      invited by Yoshi Yamaichi

      Lieu : Salle de séminaires - bâtiment 26 (TBA) - Campus CNRS de Gif-sur-Yvette

      Article

    • Vendredi 15 décembre 2017 11:00-12:00 - Wouter de Laat - Biomedical genomics group, Hubrecht Institute, Utrecht, The Netherlands

      Genome structure-function relationships explored at new dimensions

      Résumé : Chromatin folding is increasingly recognized as a regulator of genomic processes such as gene activity. Chromosome conformation capture (3C) methods have been developed to unravel genome topology through the analysis of pair-wise chromatin contacts and have identified many genes and regulatory sequences that, in populations of cells, are engaged in multiple DNA interactions. I will describe our contributions to this field and will present novel Multi-Contact 4C (MC-4C), that applies Oxford Nanopore long-read single molecule sequencing to study multi-way DNA conformations of individual alleles for distinction between cooperative, random and competing interactions. Using this single molecule multi-contact analysis method, we uncover previously missed structures in sub-populations of cells, reveal single locus enhancer hubs and demonstrate the collision of CTCF-anchored architectural loops. Insight into single allele higher-order topological features will help understanding how the myriad of regulatory sequences spatially coordinate their actions on individual chromosomes and facilitate interpreting the consequences of natural and induced genetic variation. If time permits, I will also discuss how we explore the application of 3C-based methods in DNA diagnostics, oncogenetics and non-invasive prenatal diagnosis.
      Contact : Daan Noordermeer <daan.noordermeer i2bc.paris-saclay.fr>

      Lieu : Auditorium - bâtiment 21 - Campus CNRS de Gif-sur-Yvette

      Article

  • Biologie Cellulaire

    • Vendredi 1er décembre 2017 11:00-12:00 - Stanislas TOMAVO - I2BC

      Trafic intracellulaire et biogenèse des organites sécrétoires chez Toxoplasma gondii

      Lieu : Auditorium - bâtiment 21 - campus de Gif

      Article

  • Virologie

    • Vendredi 8 décembre 2017 11:00-12:30 - Pierre-Yves Lozach - Université d’Heidelberg

      Early arbovirus-host cell interactions : from virus transmission to cell entry and pathogenesis

      Résumé : During natural transmission, arboviruses are introduced into vertebrate host skin through arthropod bites, and the life cycle of viruses switch from the cell biology of arthropod vectors to that of vertebrate hosts. Indeed, the cell biology in vertebrate hosts is different from that in arthropod vectors, the consequence being that arbovirus particles can change some components and the composition of their lipid and glycan coats during host switch. However it remains unclear whether host alternation is important at the molecular level for the early steps of infection and virus entry into the first-target host cells as well as the subsequent steps leading to the pathogenesis. Within this talk, these issues will be addressed based on the analysis of the phleboviruses Rift Valley fever and Uukuniemi in arthropod vector and mammalian host cells by state-of-the-art fluorescence-based techniques in fixed and living cells.

      Lieu : Salle de séminaires bâtiment 14C - Bât. 14C
      Campus Gif-sur-Yvette

      Article

  • cytoskeleton club

    • Mardi 12 décembre 2017 11:30-12:30 - Delphine Gogendeau

      Cytoskeleton club

      Résumé : Down-regulation of different transition zone proteins in Paramecium induces antagonistic effects on cilia stability

      Lieu : Bibliothèque - Bâtiment 34, campus de Gif

      Article

Soutenance

  • Microbiologie

    • Mercredi 6 décembre 2017 14:00-17:00 - Soumaya NAJAH - Equipe "Microbiologie moléculaire des Actinomycètes"

      Étude du métabolisme spécialisé de Streptomyces sp. TN58

      Lieu : Salle A. Kalogeropoulos - bât. 400 - Campus d’Orsay

      Article

    • Mardi 19 décembre 2017 10:00-12:00 - Hanane Issa - Equipe "Biologie Moléculaire des Corynebactéries et Mycobactéries"

      Étude de la mycoloylation des protéines chez les Corynebacteriales

      Résumé :

      Avis de soutenance ISSA

      Lieu : Salle de Conférences Lederer - Bâtiment 430 - Campus Orsay

      Article

  • B3S

    • Vendredi 22 décembre 2017 14:00-17:00 - Clément Nemoz - Equipe Enveloppe Nucléaire, Télomères et Réparation de l’ADN

      Rôle de Ku70/80 dans le recrutement des facteurs du NHEJ portant un motif de fixation à Ku

      Lieu : Auditorium I2BC - Bât. 21, Campus de Gif

      Article

Colloque

  • I2BC

    • Vendredi 8 décembre 2017 09:00-17:00 -

      YOUR-Carreer day

      Lieu : Auditorium - Bâtiment 21, campus de Gif

      Article

Journée de département

  • B3S

    • Lundi 18 décembre 2017 09:00-18:00 -

      Journée du Département B3S

      Résumé :

      Programme Journée B3S - 18 décembre 2017

      Ci-joint, le programme quasi-définitif de la journée.
      Les inscriptions sont encore possibles jusqu’à jeudi (7 décembre) en remplissant le sondage à l’adresse :
      https://doodle.com/poll/z39as2mznqzvsek4
      Si vous souhaitez présenter un poster, merci d’envoyer un titre et une liste d’auteurs (en précisant qui présentera le poster le 18/12) à Jessica Andreani

      Lieu : Auditorium - Bâtiment 21, campus Gif-sur-Yvette

      Article

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