Résumé : Signaling nucleotides are key molecules in all domains of life and control fundamental processes including central metabolic or stress response processes as well as biofilm formation. c-di-AMP is one of the more recently discovered signaling molecules and is produced by a number of bacteria including pathogens such as Staphylococcus aureus. In S. aureus, c-di-AMP is important for bacterial growth, antibiotic resistance, osmotic and pH stress tolerance. The signaling nucleotide is synthesized from two molecules of ATP by the diadenylate cyclase DacA and degraded to pApA by the phosphodiesterase GdpP. Here, recent work on the identification and characterization of additional factors regulating cellular c-di-AMP levels will be discussed. In addition, data from genome-wide interaction screens leading to the identification of c-di-AMP specific receptor proteins will be presented.
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