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20 octobre 2017: 1 événement

  • Département Biologie des Génomes

    Vendredi 20 octobre 11:00-12:00 - Dr Bertrand Séraphin - IGBMC - CNRS UMR 7104/INSERM U964/Unistra

    Starting from the end : mechanisms, regulation, and pathological implications of mRNA decay

    Résumé : In eukaryotic cells, gene expression is a complex process that is initiated in the nucleus by the transcription of pre-mRNAs followed by their processing before the export of the mature RNAs to the cytoplasm. In this compartment, mRNAs are translated, sometime after storage and/or localization, and finally degraded. Regulation at all steps of this process may contribute to the quantitative, spatial and temporal control of polypeptide production.
    It has recently become clear that mRNA decay contributes similarly to transcription to regulated protein production. We are interested to decipher the mechanisms controlling gene expression at the level of RNA decay. Eukaryotic mRNAs are protected at their two extremities by specific structures : a cap at the 5’ end and a poly(A) tail at the 3’ end. We have identified proteins involved in eliminating these protective groups and are characterizing their functions in yeast and human cells using whenever possible essential insights provided by collaborative structural analyses. Mechanisms ensuring the regulation of these factors and the control of mRNA decay will be also presented. Alterations of some of these factors in human diseases demonstrate further the physiological importance of mRNA turnover pathways.
    Contact : Michel WERNER

    Lieu : Auditorium - Bâtiment 21, Campus de Gif

    En savoir plus : Département Biologie des Génomes