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10 novembre 2017: 1 événement

  • Département Biologie des Génomes

    Vendredi 10 novembre 11:00-12:00 - Romain Koszul - Pasteur Institute

    Insights on the 4D dynamics of budding yeast mitotic and meiotic chromosomes

    Résumé : Abstract
    The duplication and segregation of chromosomes during mitosis and meiosis involve the dynamic re-organization of their internal structure by conserved architectural proteins, such as structural maintenance of chromosomes complexes (i.e. cohesin and condensin). Although the roles of these factors are actively investigated, a genome-wide overview of chromosome dynamic architecture at both small and large-scales during these two essential processes remain to be reached. I will present recent work on budding yeast : first, the comprehensive 4D analysis of higher-order genome organization during the mitotic cell cycle, and the roles of SMC in the observed structural transitions. Then, a preliminary investigation of homologs dynamics during meiosis prophase using Hi-C, a study which necessitate the redesign and reassembly of a 145kb region. We track in a synchronized meiotic population the establishment of homolog pairing, and the individualization, condensation, and internal restructuration of paired chromosomes.
    Contact : YAMAICHI Yoshiharu <yoshiharu.yamaichi>
    BOCCARD Frederic <Frederic.BOCCARD>

    Lieu : Salle des séminaires- bâtiment 26 - Campus CNRS de Gif-sur-Yvette

    En savoir plus : Département Biologie des Génomes