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26 janvier 2018: 1 événement

  • Département Biologie des Génomes

    Vendredi 26 janvier 14:00-15:00 - Yaser Hashem - Institut Européen de Chimie et de Biologie, INSERM

    Protein translation initiation in eukaryotes : A jigsaw puzzle that has barely started yielding its picture

    Résumé : Translation initiation in eukaryotes is a highly regulated and rate-limiting process. It results in the assembly and disassembly of numerous transient and intermediate complexes involving over a dozen initiation factors (eIFs). This process culminates in the accommodation of a start-codon marking the beginning of an open reading frame (ORF) at the appropriate ribosomal site. Here, we present a model of the eukaryotic translation initiation process based on recent structures mainly derived by cryo-EM. In addition, we present new results that highlight some of the structural implications of the kozak sequence on the initiation complex formation. Finally we present some of the species-specific aspects of translation initiation in Kinetoplastids, a group of pathogenic eukaryotic organisms.
    Contact : Carmela Giglione <carmela.giglione i2bc.paris-saclay.fr>

    Lieu : Bibliothèque - bâtiment 34 - Campus CNRS de Gif-sur-Yvette

    En savoir plus : Département Biologie des Génomes