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2 février 2018: 2 événements

  • Département Biologie Cellulaire

    Vendredi 2 février 11:00-12:00 - François PARCY - Institut de Biosciences et Biotechnologies de Grenoble (BIG), invité par Grégory Vert

    A structural journey among floral regulators

    Résumé : In Arabidopsis like in many other plants, the development of flowers starts on the flanks of the shoot apical meristem. The position of the floral meristem is determined by the phytohormone auxin and the Auxin Response Factor Monopteros/ARF5 protein. Soon afterwards, the LEAFY transcription factor contributes to the emergence and the floral fate of the newly formed flower meristem. I will present how the combination of molecular genetics, epigenetics, structural biology, genomics and modeling allows to better understand the basic properties of these transcription factors and their function during flower development.

    Lieu : Auditorium - bâtiment 21 - campus de Gif

    En savoir plus : Département Biologie Cellulaire
  • Département Biologie des Génomes

    Vendredi 2 février 11:00-12:00 - Anne Royou - Institut de Biochimie et Génétique Cellularies, Université de Bordeaux

    How are broken chromosomes processed and faithfully transmitted to daughter cells

    Résumé : During interphase, DNA lesions such as double strand breaks (DSB) trigger a signalling pathway called the DNA damage response (DDR) that repairs the damage while concomitantly delaying cell cycle progression. Recent studies have shown that in the presence of DSBs during mitosis, the early steps of the DDR are activated while the downstream repair pathways are inhibited. It is thought that these DNA damage sensors mark the DSBs to allow their efficient repair in the next G1 phase. However, how mitotic cells preserve faithful transmission of broken chromosome fragments while processing DSBs is not understood. We have recently identified a mechanism by which broken chromosomes are faithfully transmitted to daughter cells via the tethering of the two broken chromosome ends. This mechanism involves several mitotic proteins, including BubR1, Bub3 and Polo, which are best known for their role in monitoring the proper attachment of chromosomes to the spindle microtubules. I will present our recent findings that address how BubR1, Bub3 and Polo are recruited to DNA breaks in mitosis and address their relationship to components of the DNA damage response.
    Contact : Laure CRABBE <Laure.CRABBE i2bc.paris-saclay.fr>

    Lieu : Bibliothèque - bâtiment 34 - Campus CNRS de Gif-sur-Yvette

    En savoir plus : Département Biologie des Génomes