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20 mars 2018: 2 événements

  • Département Virologie

    Mardi 20 mars 11:00-12:30 - Franck Perez - Institut Curie, Paris

    Exploring and Exploiting the Diversity of Secretory Routes in Mammalian Cells

    Résumé : To regulate their homeostasis – to exchange signals with the extracellular environment or migrate for example – cells need to address particular proteins and lipids toward specific compartments in a tightly controlled way. Golgi-dependent trafficking plays an essential role in these processes but, although our knowledge about the mechanisms of intra-Golgi transport and sorting has dramatically increased over the past two decades, the underlying complexity of transport routes, in term of mechanism and dynamics, is only starting to emerge.
    Using our recently developed synchronized secretory system, the RUSH assay, we monitored transport of cargos to the cell surface and observed that preferred tracks exist in cells that drive protein transport to exocytosis hotspots. We also used the RUSH system to explore cell-to-cell signalling analysing the transport of GPI-anchored ephrins. Last, we are adapting the RUSH assay for High Content Screening to use the diversity of the secretory pathway to identify potential therapeutic molecules.

    Lieu : Salle de séminaire bâtiment 14C - Campus Gif-sur-Yvette

    En savoir plus : Département Virologie
  • Cytoskeleton club

    Mardi 20 mars 11:45-12:30 - Anne-Marie Pret

    Cytoskeleton club

    Résumé : JAK/STAT Signaling and Epithelial Dynamics

    Lieu : Bibliothèque - Bâtiment 34, campus de Gif

    En savoir plus : Cytoskeleton club