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Home > Research > Biochemistry, Biophysics and Structural Biology > Françoise OCHSENBEIN & Raphaël GUEROIS : Molecular Assemblies and Genome Integrity

Françoise OCHSENBEIN & Raphaël GUEROIS : Molecular Assemblies and Genome Integrity

Françoise OCHSENBEIN & Raphaël GUEROIS : Group Presentation

We combine experimental and computational strategies to unravel the molecular bases underlying the dynamic assembly of specific protein interaction networks. Focused on the complexes involved in (...)

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May BAKAIL, former PhD student (2013-2016), now post-doc at Institut Cochin
Jinchao YU, former PhD student (2013-2016), now at Pharnext
Nicolas RICHET, former PhD student (...)

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10 most recent publications

PLoS One. 2017;12(12):e0189049
Structural basis for the substrate selectivity of Helicobacter pylori NucT nuclease activity. Authors: Celma L, Corbinais C, Vercruyssen J, Veaute X, de la Sierra-Gallay IL, Guérois R, Busso D, Mathieu A, Marsin S, Quevillon-Cheruel S, Radicella JP [PubMed]

Virology. 2016 May 30;496:42-50
Phagonaute: A web-based interface for phage synteny browsing and protein function prediction. Authors: Delattre H, Souiai O, Fagoonee K, Guerois R, Petit MA [PubMed]

Prog Biophys Mol Biol. 2015 Oct;119(1):1
Editorial. Protein-Protein Interaction Analysis and Modulation. Authors: Ochsenbein F, Morelli X, Verma C [PubMed]

Bioinformatics. 2015 Dec 1;31(23):3850-2
HHalign-Kbest: exploring sub-optimal alignments for remote homology comparative modeling. Authors: Yu J, Picord G, Tuffery P, Guerois R [PubMed]

J Biol Chem. 2015 Jul 24;290(30):18721-31
New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C. Authors: Wang W, Shen T, Guerois R, Zhang F, Kuerban H, Lv Y, Gigant B, Knossow M, Wang C [PubMed]

Bioinformatics. 2015 Jun 1;31(11):1729-37
bbcontacts: prediction of β-strand pairing from direct coupling patterns. Authors: Andreani J, Söding J [PubMed]

Nucleic Acids Res. 2015 Feb 18;43(3):1905-17
Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork. Authors: Richet N, Liu D, Legrand P, Velours C, Corpet A, Gaubert A, Bakail M, Moal-Raisin G, Guerois R, Compper C, Besle A, Guichard B, Almouzni G, Ochsenbein F [PubMed]

BMC Genomics. 2014;15:1027
Automated classification of tailed bacteriophages according to their neck organization. Authors: Lopes A, Tavares P, Petit MA, Guérois R, Zinn-Justin S [PubMed]

Nucleic Acids Res. 2014 Dec 1;42(21):13174-85
Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit. Authors: Meurisse J, Bacquin A, Richet N, Charbonnier JB, Ochsenbein F, Peyroche A [PubMed]

PLoS Biol. 2014 Oct;12(10):e1001968
The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1. Authors: Pietrobon V, Fréon K, Hardy J, Costes A, Iraqui I, Ochsenbein F, Lambert SA [PubMed]

Elife. 2014;3:e03035
A structural model of the active ribosome-bound membrane protein insertase YidC. Authors: Wickles S, Singharoy A, Andreani J, Seemayer S, Bischoff L, Berninghausen O, Soeding J, Schulten K, van der Sluis EO, Beckmann R [PubMed]

Arch Biochem Biophys. 2014 Jul 15;554:65-75
Evolution of protein interactions: from interactomes to interfaces. Authors: Andreani J, Guerois R [PubMed]

Sci Rep. 2017 Aug 11;7(1):7875
Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains. Authors: Caillet-Saguy C, Toto A, Guerois R, Maisonneuve P, di Silvio E, Sawyer K, Gianni S, Wolff N [PubMed]

Mol Cell. 2017 Mar 06;:
Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes. Authors: Baejen C, Andreani J, Torkler P, Battaglia S, Schwalb B, Lidschreiber M, Maier KC, Boltendahl A, Rus P, Esslinger S, Söding J, Cramer P [PubMed]

Elife. 2017 Mar 18;6:
Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1. Authors: Sauer PV, Timm J, Liu D, Sitbon D, Boeri-Erba E, Velours C, Mücke N, Langowski J, Ochsenbein F, Almouzni G, Panne D [PubMed]

Bioinformatics. 2016 Aug 22;
PPI4DOCK: Large scale assessment of the use of homology models in free docking over more than 1000 realistic targets. Authors: Yu J, Guerois R [PubMed]

Elife. 2017 Jan 04;6:
Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion. Authors: Duroc Y, Kumar R, Ranjha L, Adam C, Guérois R, Md Muntaz K, Marsolier-Kergoat MC, Dingli F, Laureau R, Loew D, Llorente B, Charbonnier JB, Cejka P, Borde V [PubMed]

Acta Crystallogr F Struct Biol Commun. 2016 Mar 1;72(Pt 3):198-206
Structure of a truncated form of leucine zipper II of JIP3 reveals an unexpected antiparallel coiled-coil arrangement. Authors: Llinas P, Chenon M, Nguyen TQ, Moreira C, de Régibus A, Coquard A, Ramos MJ, Guérois R, Fernandes PA, Ménétrey J [PubMed]

J Cell Sci. 2016 Sep 2;
Direct interaction between Exocyst and Wave complexes promotes cell protrusions and motility. Authors: Biondini M, Sadou-Dubourgnoux A, Paul-Gilloteaux P, Zago G, Arslanhan MD, Waharte F, Formstecher E, Hertzog M, Yu J, Guerois R, Gautreau A, Scita G, Camonis J, Parrini MC [PubMed]

J Clin Invest. 2017 Sep 25;:
Mutations in the netrin-1 gene cause congenital mirror movements. Authors: Méneret A, Franz EA, Trouillard O, Oliver TC, Zagar Y, Robertson SP, Welniarz Q, Gardner RJM, Gallea C, Srour M, Depienne C, Jasoni CL, Dubacq C, Riant F, Lamy JC, Morel MP, Guérois R, Andreani J, Fouquet C, Doulazmi M, Vidailhet M, Rouleau GA, Brice A, Chédotal A, Dusart I, Roze E, Markie D [PubMed]

PLoS One. 2017;12(10):e0186354
Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain. Authors: Nguyen TQ, Chenon M, Vilela F, Velours C, Aumont-Nicaise M, Andreani J, Varela PF, Llinas P, Ménétrey J [PubMed]

Proteins. 2016 Oct 4;:
Lessons from (co-)evolution in the docking of proteins and peptides for CAPRI Rounds 28-35. Authors: Yu J, Andreani J, Ochsenbein F, Guerois R [PubMed]

Proteins. 2016 Apr 28;
Prediction of homo- and hetero-protein complexes by protein docking and template-based modeling: a CASP-CAPRI experiment. Authors: Lensink MF, Velankar S, Kryshtafovych A, Huang SY, Schneidman-Duhovny D, Sali A, Segura J, Fernandez-Fuentes N, Viswanath S, Elber R, Grudinin S, Popov P, Neveu E, Lee H, Baek M, Park S, Heo L, Rie Lee G, Seok C, Qin S, Zhou HX, Ritchie DW, Maigret B, Devignes MD, Ghoorah A, Torchala M, Chaleil RA, Bates PA, Ben-Zeev E, Eisenstein M, Negi SS, Weng Z, Vreven T, Pierce BG, Borrman TM, Yu J, Ochsenbein F, Guerois R, Vangone A, Rodrigues JP, van Zundert G, Nellen M, Xue L, Karaca E, Melquiond AS, Visscher K, Kastritis PL, Bonvin AM, Xu X, Qiu L, Yan C, Li J, Ma Z, Cheng J, Zou X, Shen Y, Peterson LX, Kim HR, Roy A, Han X, Esquivel-Rodriguez J, Kihara D, Yu X, Bruce NJ, Fuller JC, Wade RC, Anishchenko I, Kundrotas PJ, Vakser IA, Imai K, Yamada K, Oda T, Nakamura T, Tomii K, Pallara C, Romero-Durana M, Jiménez-García B, Moal IH, Férnandez-Recio J, Joung JY, Kim JY, Joo K, Lee J, Kozakov D, Vajda S, Mottarella S, Hall DR, Beglov D, Mamonov A, Xia B, Bohnuud T, Del Carpio CA, Ichiishi E, Marze N, Kuroda D, Roy Burman SS, Gray JJ, Chermak E, Cavallo L, Oliva R, Tovchigrechko A, Wodak SJ [PubMed]

Nucleic Acids Res. 2016 Apr 29;
InterEvDock: a docking server to predict the structure of protein-protein interactions using evolutionary information. Authors: Yu J, Vavrusa M, Andreani J, Rey J, Tufféry P, Guerois R [PubMed]

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Join us

If you would like to join our team, please contact Françoise Ochsenbein or Raphaël Guerois.
​Loc​​ation of the laboratory: CEA Saclay
Contacts (...)

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