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Accueil > Départements > Biochimie, Biophysique et Biologie Structurale > Christophe LE CLAINCHE & Louis RENAULT : Dynamique du cytosquelette et motilité

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NCBI : db=pubmed ; Term=( ("Renault L"[author] OR ("Renault L"[author] AND ("Le clainche C"[author] OR "DAVID V"[author] OR "HENRIOT V"[author] OR "LAI TL"[author] OR "WANG H"[author] OR "FELLOUS S"[author]))) AND "2014/01/01"[Date - Publication] : "3000"[Date - Publication] ) AND ("Laboratoire d’Enzymologie et Biochimie Structurales"[Affiliation] OR I2BC[Affiliation] OR "Institute for Integrative Biology of the Cell"[Affiliation])

Articles syndiqués

  • ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa : A minireview.

    21 décembre 2017, par Belyy A, Mechold U, Renault L, Ladant D
    Related Articles

    ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview.

    Toxicon. 2017 Dec 16;:

    Authors: Belyy A, Mechold U, Renault L, Ladant D

    Abstract
    ExoY is one of four well-characterized Pseudomonas aeruginosa type 3 secretion system (T3SS) effectors. It is a nucleotidyl cyclase toxin that is inactive inside the bacteria, but becomes potently activated once it is delivered into the eukaryotic target cells. Recently, filamentous actin was identified as the eukaryotic cofactor that stimulates specifically ExoY enzymatic activity by several orders of magnitude. In this review, we discuss recent advances in understanding the biochemistry of nucleotidyl cyclase activity of ExoY and its regulation by interaction with filamentous actin.

    PMID: 29258848 [PubMed - as supplied by publisher]