Strategic axes confront the future
infectious diseases and symbiosis
Host-microbe interactions: infectious diseases and symbiosis
Virus, bacteria, archaea, parasites and yeast have evolved to be able to invade a wide range of hosts in a symbiotic or pathogenic manner. They are also able to modify the host biological processes (transcription, translation, transport, etc.), inhibit the host defenses, put in place new cellular compartments, or modify expression of the host genome. Moreover, these microorganisms can rapidly mutate, incorporate new genes into their genome or transfer genes into the host genome, playing a major role in the evolution of species. As we have seen with the current pandemic, it is important to continue to study these organisms using a multitude of approaches and techniques.
SCIENTIFIC CHALLENGES FOR I2BC
- Understand how microbes interact, invade, persist, proliferate, evade, differentiate and/or cause disease in the host cell.
- Analyze the origin, dissemination and evolution of microbes resistance to drugs.
- Study the host defense mechanisms, including how the host reprograms to fight against the microbe.
- Develop new antimicrobial strategies.