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Accueil > Séminaires

Département Biologie Cellulaire

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  • Vendredi 21 juin 11:30-12:30 - Aeid IGBARIA - COSS Laboratory, Université de Rennes

    ER resident proteins reflux, a functional ER surveillance mechanism during stress and disease

    Résumé : Diverse perturbations to endoplasmic reticulum (ER) functions compromise the proper folding and structural maturation of secretory proteins causing ER stress. Recently, we found that diverse ER stress regimes cause properly folded, ER-resident eroGFP (and other ER luminal proteins) to “reflux” back to the reducing environment of the cytosol as intact, folded proteins. By performing a comprehensive genetic screen in Saccharomyces cerevisiae, we found that ER protein reflux during ER stress requires specific chaperones and cochaperones residing in both the ER and the cytosol. Chaperone mediated ER protein reflux proceeds more vigorously when ER-associated degradation (ERAD) factors are crippled, suggesting that reflux may work in parallel with ERAD. Finally, we found that ER protein reflux is conserved in mammalian cells, regulated by the IRE1a kinase/endoribonuclease and may play preeminent role in human diseases. In summary, chaperone-mediated ER protein reflux may play as a conserved protein quality control process that evolved to maintain secretory pathway homeostasis during ER protein-folding stress.

    Lieu : Bibliothèque - bâtiment 34 - campus de Gif-sur-Yvette

  • Lundi 24 juin 14:00-17:00 - Christophe Lefebvre - I2BC - Equipe Autophagie et Développement

    Interaction entre réticulum endoplasmique et Autophagie chez le nématode Caenorhabditis elegans

    Lieu : Auditorium I2BC - Bat. 21, Campus de Gif-sur-Yvette

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