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Département Biologie des Génomes

par Clubs génome, EQYY - publié le , mis à jour le


  • Lundi 10 septembre 11:00-12:00 - Sander Granneman - Centre for Synthetic and Systems Biology (SynthSys) University of Edinburgh

    Post-transcriptional regulation of adaptive responses in microorganisms

    Résumé : Work in my lab is focusing on understanding how microorganisms manage to rapidly adapt (and even thrive) to sudden changes in their environment. Many pathogenic species have developed very sophisticated mechanisms to efficiently scavenge essential nutrients from the host environment and even evade the immune system.
    We hypothesize that this successful rapid adaptation program is underpinned by the ability of the microorganism to very rapidly remodel its gene expression profile.
    Obviously, transcription factors largely dictate which genes are switched on and off during adaptive responses. However, it is becoming increasingly clear that post-transcriptional regulation plays a key role in this process by shaping gene expression profiles. Small non-coding RNAs (sRNAs) and RNA-binding proteins (RBPs) are believed to play a crucial role in post-transcriptional regulation by modulating the translation efficiency and stability of mRNA targets. However, for the vast majority their function is unknown, underscoring the need for a thorough analysis of these molecules.
    Over the years my group has developed a number of powerful high-throughput methods that enable us to unravel post-transcriptional regulatory networks controlled by non-coding RNAs and RBPs. Our initial studies in yeast uncovered a novel role for RBPs in co-transcriptionally controlling the expression kinetics of stress-responsive genes as well as targets for thousands of bacterial sRNAs. We are currently expanding our research into pathogenic bacteria. Collectively, our data provide intriguing insights into how non-coding RNAs and RBPs are employed to fine-tune gene expression in response to stress. Results from these studies will be presented.
    Contact : ROUGEMAILLE Mathieu <Mathieu.ROUGEMAILLE>

    Lieu : Bibliothèque- bâtiment 34 - Campus CNRS de Gif-sur-Yvette

    Notes de dernières minutes : Demo of the Vari-X-linker will follow (14h ) at CEA Saclay (building 144). Contact Mathieu for participation. Be careful CEA requires authorization to enter the campus

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