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Département Biologie des Génomes

par Clubs génome, EQYY - publié le , mis à jour le


  • Vendredi 29 mars 11:00-12:00 - Claude Bruand - Laboratoire des Interactions Plantes-Microorganismes (LIPM), Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France

    Non-homologous end-joining in bacteria : from DNA double-strand break repair to acquisition of heterologous DNA

    Résumé : DNA double-strand breaks (DSB) in bacteria can be repaired either by homologous recombination dependent on the universal RecA protein, or by non-homologous end-joining (NHEJ), a two-component system relying on the Ku and LigD proteins, present in 20 % of bacterial species. Strikingly, Sinorhizobium meliloti encodes several potential Ku and LigD proteins, which prompted us to perform a comprehensive genetic analysis of NHEJ in this bacterial species. We report here the results of this study, which brings new insights into the mechanism, regulation and putative function of NHEJ in bacteria.
    Dupuy P., Sauviac L. and Bruand C. (2018) Stress-inducible NHEJ in bacteria : function in DNA repair and acquisition of heterologous DNA. Nucleic Acids Res. doi : 10.1093/nar/gky1212.
    Bertrand C., Thibessard A., Bruand C., Lecointe F., Leblond P. (2019) NHEJ in bacteria : a never ending story. Mol Microbiol. doi : 10.1111/mmi.14218
    Contact : Julien Bischerour and Mireille Bétermier

    Lieu : Salle des séminaires- bâtiment 26 - Campus CNRS de Gif-sur-Yvette

  • Vendredi 5 avril 11:00-12:00 - Charles Dorman - Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Ireland

    Bacterial decision-making

    Résumé : The model organism Escherichia coli inhabits a series of environments that impose on the bacterium a need to be nimble in making adjustments to its composition and physiology if it is to survive and thrive. E. coli provides a good experimental system for understanding how bacteria in general interpret their surroundings and make appropriate responses to change, a process that can be described as decision making. Decisions are made at the level of individual cells but are made manifest at the level of the whole bacterial population. In this lecture the dynamic structure of the E. coli nucleoid will be compared to the workings of a primitive brain and adjustments to the 4-dimensional structure of the nucleoid will be considered in terms of their impact on the operation of a genetic switch that governs the composition of the bacterial cell surface and the ability of the individual bacterium to adhere to surfaces in the animal or human host or in the external environment. Finally, the implications of this decision-making process will be considered for the creation of physiological diversity within a genetically homogenous bacterial population and for influencing the reversible commitment to either an independent (planktonic) style of living or to a community-based strategy within a biofilm.

    Lieu : Bibliothèque Bât. 34 - Campus de Gif-sur-Yvette

    Notes de dernières minutes : The Chair of Microbiology at Trinity College Dublin was established 100 years ago (in 1919) as the Chair of Bacteriology and Preventive Medicine. Charles Dorman has held this chair for the past 25 years. He is a Member of the Royal Irish Academy, a Fellow of the American Academy of Microbiology, a Fellow of the Royal Society of Biology, a founding member of the European Academy of Microbiology, a Trustee of the Microbiology Society (London) and a Science Foundation Ireland Principal Investigator. Professor Dorman has published over 200 articles on the topic of bacterial gene regulation.

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