Séminaires Génomes
Les événements du département Biologie des Génomes sont affichés en rouge dans l’agenda I2BC...
Contact : Yoshiharu YAMAICHI
Agenda
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Lundi 22 mars 16:00-17:00 - Xindan Wang - Indiana University Title to be announced Résumé : Invited by Christophe Possoz.
Due to the time difference, the seminar will be exceptionally held at 16h00 (11h00 EDT)Lieu : Visio
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Vendredi 26 mars 11:00-12:00 - Dagmara Jakimowicz - University of Wroclaw title to be announced Résumé : Abstract to be communicated
Invited by Vicky LioyLieu : visio
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Vendredi 16 avril 11:00-12:00 - Jose Antonio ESCUDERO - Universidad Complutense de Madrid Evolutionary History of Integrons Résumé : Integrons are genetic platforms that act as bacterial memories of adaptive functions, accelerating evolution in changing environments. They were discovered on conjugative plasmids for their role in the early rise of multidrug resistance, but they are naturally found in the chromosomes of many bacterial species, where they have driven their evolution for aeons. Integrons recruit, stockpile and modulate the expression of new genes encoded in small mobile structures named cassettes. The streamlined functionality of integrons is based on the DNA transactions performed by the integrase –that integrates, excises and reshuffles cassettes-, and the peculiarities of the recombination sites.
Yet integrons have an interesting evolutionary origin themselves. In this seminar, we will see how they have evolved from the tyrosine recombinase family of proteins through a process of evolutionary innovation. I will explain how the activity of these ancestors has been extensively modified to deliver the modern activity of today’s integrases through the co-evolution of the integrase and the attC recombination site. We will discuss the main biological implications of this evolutionary process in an attempt to establish the selective forces driving it, and the meaning of the coexistence of ancestral and modern activities. We will end by deciphering the structural basis of both activities and their trade-offs through an attempt to rewind the tape of evolutionary innovation.
Invited by Virginia Lioy Lioy <virginia.lioy i2bc.paris-saclay.fr>Lieu : visio
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Vendredi 23 avril 16:00-17:00 - Josh Beck - Iowa State University Title to be announced (NOTE : CHANGE OF TIME) Résumé : TO BE ANNOUNCED
Invited by Joana SantosLieu : visio
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Vendredi 4 juin 11:00-12:00 - Arthur Talman - MiVEGEC - IRD Montpellier To be announced Résumé : To be communicated
Invited by Joana Santos
