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Post-Doctoral position at the Virology Department
A 3 years post-doc position granted by ANRS is available starting from January 2019
The post-doc will join a dynamic research team from the Virology dpt. focusing on virus-host interactions in particular cellular degradation compartments such as autophagy. The group of A. Moris is currently at CIMI-Paris but will move to I2BC in 2019 to dissect the pathways leading to viral antigen presentation by MHC molecules to human T lymphocytes.

Project
The postdoc will characterize the various steps leading to MHC-II-restricted antigen presentation by B cells, from antigen capture mediated by the B-cell-receptor to MHC-II loading compartments and the quality of T cell activation. The project includes the development and characterization of novel libraries of antigen specific human B cells. Our aim is to define the checkpoints and rate-limiting steps of antigen presentation by B cells to help designing novel vaccine strategies that will sustain B-cell-T-cell antigen-specific interactions and thus the generation of broadly Neutralizing Antibodies.
The team has tight contacts with researchers and clinicians involved in HIV research and in charge of patient cohorts. The post doc salary is granted by the French AIDS agency (ANRS) as part of a collaborative work with Hugo Mouquet from the Pasteur Institute.

The candidate
We are interested in rigorous and multi-talented candidates who are enthusiastic and passionate about tackling basic biological questions with potential application in immunotherapy. The candidate should have a PhD in Immunology or Cellular Biology. This position is particularly suited for applicants with a strong background in the field of B cell biology. However, candidates with an expertise in cell biology (e.g. culture of primary human cells, vesicular trafficking and imaging) are also highly encouraged to apply.
Competences in basic molecular biology technics will be appreciated. The candidate should be strongly motivated to develop an innovative project in the field of infectious diseases with a focus on HIV research. The applicant must demonstrate a capacity to rapidly adapt to a new environment ; to show initiative in interacting with colleagues from the team, the dpt, the core facilities and I2BC.

Applications : Candidates should send a motivation letter, CV and contacts of 3 references to Arnaud Moris
Starting date : The position is opened from January 2019.

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Technician position at the Cell Biology Department
Position on Arabidopsis molecular genetics
A position is available at the Institute for Integrative Biology of the Cell in Gif-sur-Yvette, I2BC (http://www.i2bc.paris-saclay.fr/). This position is funded in the context of the project “Improving Seed Iron STORage” (ISISTOR) funded by the ANR. The position is open for technicians or engineers for a duration of 12 months starting in October 2018.

Topic and missions
Seeds contain all the nutrients required for the development of a new organism, including iron which is frequently limiting in the human diet. Seeds are most often the edible part of crops. The objective of the project is to identify novel genes involved in the control of iron storage and remobilisation in seeds using a genetic approach. The candidate will be involved in the identification and characterization of Arabidopsis thaliana mutants : plant culture under controlled conditions, analysis of NGS data, construction of plant transformation vector, Arabidopsis transformation, genotyping and physiological analyses. The goal of this research is to identify candidate genes to improve iron availability in crop seeds.

Profile
The candidate should have a training in molecular biology. Experience in plant in vitro culture, Arabidopsis transformation and NGS data analysis will be appreciated. The candidate should be highly motivated and ready to interact within an international team.

Salary : according to experience and degree.
Starting date : from October to December 2018.
Applications : a CV, a statement of interest for the project and contact information for 2 references should be sent to Sébastien THOMINE before September 15th, 2018.

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