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Offres d’emploi

Two-years Postdoctoral position
A two-year post-doctoral position funded by collaborative project grant of the ANR (The French National Research Agency), is available from February 2021 in the laboratory “Regulatory RNAs in Clostridia” headed by Olga Soutourina, Professor in Paris-Saclay University, at the Institute for Integrative Biology of the Cell in Paris region, France.

The post-doctoral fellow will be in charge of the microbiological part of the exciting collaborative project combining microbiology and rodent physiology to advance therapeutic tools against diabetes based on intestinal bacteria naturally producing metabolites, which are negatively associated with type 2 diabetes in humans. We will isolate and engineer bacterial species using the genetic tools developed by the team to promote their enzymatic capacity to naturally produce metabolites. The regulation of metabolic gene expression will be studied in relation to the production of metabolites. These species will be inoculated in preclinical models of type 2 diabetes and obesity in order to test the therapeutic value of intestinal enrichment in these bacteria on the severity and inheritance of diabetes phenotypes. This research, which addresses the phenomenon of crosstalk between the gastrointestinal microbiota and the host physiology, and its contribution to diabetes etiopathogenesis, may foster future clinical developments and provide new microbiota-based therapeutic solutions to reduce hyperglycemia in diabetic patients.

The successful candidate will have a PhD in microbiology or molecular biology with solid background knowledge in bacterial genetics and metabolic engineering. We are seeking for highly motivated candidates with a strong interest in the field of microbiota-host interactions. The previous experience in the manipulation of bacterial genomes (allelic exchange tools, CRISPR-Cas), regulation of gene expression and/or physiology of anaerobic bacteria will be useful for this project. Skills in high-throughput sequencing methods and analysis of metagenomic data would also be recommended. Experience in the cultivation and handling of strictly anaerobic bacteria would be a plus. Good communication skills in English are required.

Interested candidates should contact Pr. Olga Soutourina and send a Curriculum Vitae, including past research experiences and publication records, as well as a letter detailing their motivation and interest in our project. Applicants should also provide the names and contact details for two or three references and recommendation letters.


One-year Postdoctoral position
A one-year postdoctoral position funded by DIM1 Health (Région Ile-de France) starting beginning of 2021 is available in the research group "Transcription regulation in the malaria parasite" to work on characterization of a nuclear protein complex from Plasmodium falciparum.
The postdoctoral researcher will work in a project combining parasitology, proteomics and biochemistry, as part of a new ATIP-Avenir team at the Genome Biology department of the I2BC. The goal of the project is to determine how two essential nuclear proteins from the malaria parasite, Plasmodium falciparum, interact to then design protein complex inhibitors. The postdoc will collaborate with two teams, one from the I2BC and one from IPSIT, to reach the project goals.

The I2BC is a University of Paris-Saclay/CNRS/CEA research unit situated in the research campus of Gif-sur-Yvette, 35km southwest of Paris. The campus is in close proximity to a natural park and is deserved by public transportation with direct access to Paris. The institute hosts around 750 people among 60 research teams and 14 state-of-the-art technical facilities.

To apply, please send a letter of motivation, CV and the coordinates of 2 referees to Joana Santos.


Two-years Postdoctoral position
A two-year postdoctoral position funded by the French National Research Agency (ANR) is available at the research group of « Intracellular Trafficking and Organelle Biogenesis of Toxoplasma » in the Institute for Integrative Biology of the Cell (I2BC), UMR 9198 CNRS-CEA, and Paris-Saclay University (South Paris University). Our group is interested in the intracellular trafficking of proteins and lipids that are involved in the biogenesis of secretory organelles known to play key roles in infection of hosts by Toxoplasma gondii. The current project will focus on the functional analyses of newly identified parasite’s proteins that bind to lipids, which are likely involved in the membrane trafficking from the post-Golgi/endosome-like compartement (ELC) to the secretory organelles of T. gondii. By using a combination of approaches including cell biology and biochemistry, we aim to decipher the roles of these novel proteins in the formation of membrane-bound vesicles that are required for secretory organelle biogenesis.

The applicant should have a strong background in cell and molecular biology. Prior experience in imaging (confocal microscopy) analyses and biochemical methods to study protein-protein (IP) will be highly advantageous. The ideal candidate should be highly motivated, curious and will be actively involved in interdisciplinary research with renowned laboratories and core facilities of the Institute for Integrative Biology of the Cell (I2BC). A good level in English (written and spoken) is required. Review of applications will begin immediately until the position filled.

Interested candidates should send by e-mail their CV, a list of two or three references and a cover letter stating their research experience and interests to Dr Stanislas Tomavo



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