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Accueil > Départements > Biologie Cellulaire > Sébastien THOMINE : Approches Intégratives du Transport des Ions

Hyperaccumulation des métaux

Coordinator : Sylvain MERLOT

In the context of sustainable development, we observe a renewed interest for the study of metal or trace element tolerance and hyperaccumulation in plants. New knowledge in this field of research is necessary to support the development of sustainable phytotechnologies such as Biofortification, Phytoremediation, Ecocatalysis or Agromining.

In this project, we combine our strong expertise in metal homeostasis in plants with the more recent development of RNA-Seq technology and bioinformatics to identify the molecular mechanisms involved in metal tolerance and hyper accumulation in a wide diversity of plant species.

We have now identified candidate genes for convergent and species-specific mechanisms involved in nickel hyperaccumulation in plants and we are currently validating their role in the model hyperaccumulator Noccaea caerulescens (image below).

Our main goal is to obtain an integrated understanding of these mechanisms from the plant in its metalliferous environment to the regulation of the key proteins in involved in the transport of metal in cells. We also aim to provide target genes to study the evolution of metal tolerance and hyperaccumulation and to engineer plants with better metal tolerance and accumulation capabilities.

We are very enthusiastic about our project and want to develop its multidisciplinary potential including Evolution Biology, Ecology, Molecular Genetics and Genomics, Plant Physiology, Agronomy and Chemistry. Please do not hesitate to contact us if you want to collaborate or directly work with us.

We will try to regularly update information about the evolution of the project, publications and available job position on our webpage but you can also follow us on twitter @Metal_Hype.



Our research was recently supported by the French National Research Agency (ANR) through the EVOMETONICKS project and by the CNRS interdisciplinary project GENE-4-CHEM and X-TrEM.

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