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The Bettencourt Coups d’élan for French research prize awarded to Yves Gaudin

The names of the 2019 winners of the scientific prizes awarded by the Bettencourt Schueller Foundation were announced on 20 November 2019 during the awards ceremony at the André and Liliane Bettencourt auditorium of the Institut de France.
Among these laureates, Yves Gaudin’s work on viral factories was rewarded with the Coups d’élan for French research prize.

The Bettencourt Coups d’élan for French research prize is awarded each year to four French laboratories of the CNRS and INSERM. It helps to improve the infrastructure and working conditions of researchers.
Yves Gaudin, head of the Virology department of the I2BC and in charge of the Rhabdovirus team, saw his team’s work on the viral factories responsible for the replication of the rabies virus honoured by this award.

Yves Gaudin, Prix Coups d'élan 2019
Yves Gaudin, Prix Coups d’élan 2019
@Jean Picon pour la Fondation Bettencourt Schueller

The rabies virus has not disappeared ; it is responsible for 50,000 deaths per year worldwide and no treatment is possible once the disease has broken out. Only vaccination protects.

Inside the cell, the virus uses cellular energy and machinery to produce new viral particles. Inclusions of 0.5 to 3 µm in diameter called Negri bodies are observed in the cytoplasm of the infected cell. These inclusions correspond to viral factories created by the virus and dedicated to its replication. They are liquid organelles. They are therefore not delimited by a membrane but are formed by liquid phase separation, a bit like drops of oil in water. They are very dynamic and very sensitive to their environment and its evolution. They can sequester the machinery of infected cells that the virus needs to replicate.

The research work of Yves Gaudin and his team aims to understand the formation mechanisms and functioning of these viral factories. They can help open up new opportunities for antiviral strategies targeting these liquid factories, not only to treat rabies but also other viral diseases with similar virus replication strategies in infected cells, such as measles, mumps or Ebola.
The Bettencourt Coups d’élan award will allow the purchase of a confocal spinning disc microscope to perform real-time imaging on infected cells.

More information :
Bettencourt Schueller Foundation Awards Ceremony
Research Project Presentation Page

Contact :
Yves Gaudin

par Communication - publié le