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Club Mitochondrie

Follow us : @ClubMitochondrie

JPEG - 82.1 ko
mitochondria network in 3D

Who are we :
The Club Mitochondrie is attached to the Cell Biology department of the I2BC, but open to anyone interested in this fascinating organelle. It was initiated in 2020 by Agnès Delahodde and Nathalie Bonnefoy. It aims at connecting the I2BC, French researchers and researchers outside France working on different aspects of mitochondrial biology. Since January 2021 the organizers are Francesca Giordano and Inge Kühl .

How does it work :
The Club Mitochondrie would like to be as interactive and diverse as possible. We will invite external speakers, but we aim also at presenting informal talks, novel techniques and exchange ideas and knowledge. Anyone of the club who would like to present some research, a novel method or a exciting paper is encouraged to contact us. Suggestions for external speakers are very welcome as well.

When and where :
The Club Mitochondrie meets once a month, every third Tuesday at 15:00 CET either virtually or in the lecture hall of building 21 on the I2BC campus in Gif-sur-Yvette. In a Corona-free future we aim at a combination of physical and virtual meetings. Please join the virtual meeting with your full name.

Upcoming seminars :
- 16/03/2021
Arnaud Mourier - Institut de Biochimie et de Génétique Cellulaires, CNRS-UMR5095, Bordeaux

2021 schedule

- 20/04/2021
Arnaud Chevalier - Institut de Chimie des Substances Naturelles, UPR-CNRS 2301, Gif-sur-Yvette

- 18/05/2021
Julien Prudent - MRC Mitochondrial Biology Unit, Cambridge, UK

- 15/06/2021
Benoît Kornmann - University of Oxford, Oxford, UK

- 21/09/2021
To be announced

- 19/10/2021
To be announced

- 16/11/2021
Maya Schuldiner - Weizmann Institute of Sciences, Rehovot, Israel

- 21/12/2021
To be announced

Past seminars

- 16/02/2021
Nina Bonekamp - Max Planck Institute for Biology of Ageing, Cologne, Germany
"Inhibitors of mitochondrial transcription (IMTs) - novel chemical biology tools to manipulate mtDNA expression in vitro and in vivo"
- 20/01/2021
Timothy Wai – Pasteur Institut, Paris
“Mitochondrial dynamics in health and disease”


par Communication - publié le , mis à jour le

Agenda

  • Mardi 16 mars 15:00-16:00 - Arnaud MOURIER - University of Bordeaux, CNRS, IBGC, Bordeaux, France

    MDH2 is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle

    Résumé : Mitochondria are best known as the ‘powerhouses’ that supply eukaryotes with energy in the form of ATP. Beyond ATP synthesis, mitochondrial maintenance of NAD(P)H/NAD(P)+ redox cofactor balance is of paramount importance for numerous mitochondrial and cytosolic metabolic processes. However, the specific metabolic regulations allowing mitochondrial respiration to prioritize NADH oxidation in response to high NADH/NAD+ redox stress have not been elucidated. The recent discovery that complex I (NADH dehydrogenase), and not complex II (Succinate dehydrogenase), can assemble with other respiratory chain (RC) complexes to form functional entities called respirasomes, led to the assumption that this supramolecular organisation could favour NADH oxidation. However, the metabolic and physiological roles played by respirasome is much debated.
    Characterization of metabolically active heart and liver mitochondria demonstrates that unexpectedly, the RC systematically favours electrons provided by the ‘respirasome-free’ complex II. However, our results demonstrate that succinate driven respiration is tightly controlled by OAA levels, and that OAA feedback inhibition of complex II rewires RC fuelling increasing NADH oxidation capacity. This new regulatory mechanism synergistically increases RC’s NADH oxidative capacity and rewires MDH2 driven anaplerosis of the TCA, preventing malate production from succinate to favour oxidation of cytosolic malate. The MDH2-mediated rewiring of the fuelling of mitochondrial RC and TCA anaplerosis mechanically increases the capacity of the RC to indirectly maintain the cytosolic redox (NADH/NAD+) balance.

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