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Cytoskeleton club

Welcome on the I2BC Cytoskeleton Club webpage !
 
Cytoskeleton Club aims at gathering the I2BC cytoskeleton community in order to meet, present informal talks and exchange ideas and knowledge.
 
This is not a private club. Talks are open to everyone, so come along !
Cytoskeletal Club meets once a month, every second Tuesday morning at 11:30 am in the library of Building 34.

Next meeting : Tuesday June 12, 11:30 am, Bd 34 Library !
 
Hong Wang - ACTIN - Talin inhibits actin polymerization
 

 
Rules :

  1. The speaker (PIs, Post-doc, PhD, master student, Engineers) prepares a 30 minute presentation in english. Please also include your negative, unexplained, puzzling, preliminary findings and current troubles and how you solved problems that you reported last time so that everybody can give feedback and learn from each other.
  2. Disruption of the speaker with questions/suggestions from the audience (other than PIs) is positively encouraged. PIs are only allowed to ask questions after the talk and after the first question has been asked by a student or postdoc.
  3. Take part actively : Ask when you don’t understand something. Ask if you don’t know how an experiment was done. Ask what it means. You don’t need to have a PhD to ask questions.
  4. Cytoskeleton Club is like Fight Club... please don’t talk to outsiders about unpublished results that you see at these meetings.
  5. At the end of each meeting, the next speaker will be identified.

 
Club managers : Julie Ménétrey and Christophe Le Clainche
 
Members (up so far) :
Benoît Gigant and Julie Ménétrey lab - MIKICA
Christophe Le Clainche and Louis Renault lab - ACTIN
Anne-Marie Tassin lab - BIOCIL
Béatrice Satiat-Jeunemaître lab - PHOT
Anne-Marie Pret lab - SIGDEV
Francesca Giordano lab - COAST
Audrey Esclatine lab - HERPES

 
Subscription to the club / Mailing list :
To receive regular reminders, or modifications, or to ask questions, it is better to subscribe to the "CytoskeletonClub" mailing-list. In exchange for this registration, you will be called to assure one of the presentations of the Cytoskeleton Club. Please contact Julie Ménétrey or Christophe Le Clainche.
 
Flyer :

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Previous Cytoskeleton Club Seminars :
- 10/04/2018 : Francesca Giordano - COAST - Staying in touch : ORP5-mediated lipid exchange at ER-mitochondria contact sites and impact on mitochondria calcium homeostasis
- 20/03/2018 : Anne-Marie Pret - SIGDEV - JAK/STAT Signaling and Epithelial Dynamics
- 13/02/2018 : Louis Renault - ACTIN - How ExoY-Like bacterial nucleotidyl cyclase toxins from Pseudomonas aeruginosa and Vibrio nigripulchritudo are activated in host cells ?
- 9/01/2018 : Audrey Esclatine - HERPES - A protein of Epstein-Barr-Virus perturbs mitochondrial dynamics by promoting mitochondrial fission followed by mitophagy
- 12/12/2017 : Anne-Marie Tassin and Delphine Gogendeau - BIOCIL - Down-regulation of different transition zone proteins in Paramecium induces antagonistic effects on cilia stability
- 14/11/2017 : Julie Ménétrey - MIKICA - How kinesin motors recruit their cargos for MT-based transport : a structural point of view
- 12/09/2017 : Christophe Le Clainche - ACTIN - Understanding cellular force response through the in vitro reconstitution of mechanosensitive protein machineries
 



par MiKiCa - publié le

Agenda

  • Mardi 12 septembre 2017 11:30-12:30 - Christophe Le Clainche

    Cytoskeleton Club

    Résumé : Understanding cellular force response through the in vitro reconstitution of mechanosensitive protein machineries

    Lieu : Bibliothèque - Bâtiment 34, campus de Gif


  • Mardi 10 octobre 2017 11:30-12:30 - Annulée

    Cytoskeleton club

  • Mardi 14 novembre 2017 11:30-12:30 - Julie Ménétrey

    Cytoskeleton club

    Résumé : How kinesin motors recruit their cargos for MT-based transport : a structural point of view

    Lieu : Bibliothèque - Bâtiment 34, campus de Gif


  • Mardi 12 décembre 2017 11:30-12:30 - Delphine Gogendeau

    Cytoskeleton club

    Résumé : Down-regulation of different transition zone proteins in Paramecium induces antagonistic effects on cilia stability

    Lieu : Bibliothèque - Bâtiment 34, campus de Gif


  • Mardi 9 janvier 11:30-12:30 - Audrey Esclatine

    Cytoskeleton club

    Résumé : A protein of Epstein-Barr-Virus perturbs mitochondrial dynamics by promoting mitochondrial fission followed by mitophagy

    Lieu : Bibliothèque - Bâtiment 34, campus de gif


  • Mardi 13 février 11:30-12:30 - Louis Renault

    Cytoskeleton club

    Résumé : How ExoY-Like bacterial nucleotidyl cyclase toxins from Pseudomonas aeruginosa and Vibrio nigripulchritudo are activated in host cells ?

    Lieu : Bibliothèque - Bâtiment 34, campus de Gif


  • Mardi 20 mars 11:45-12:30 - Anne-Marie Pret

    Cytoskeleton club

    Résumé : JAK/STAT Signaling and Epithelial Dynamics

    Lieu : Bibliothèque - Bâtiment 34, campus de Gif


  • Mardi 10 avril 11:30-12:30 - Francesca Giordano

    Cytoskeleton club

    Résumé : Staying in touch : ORP5-mediated lipid exchange at ER-mitochondria contact sites and impact on mitochondria calcium homeostasis

    Lieu : Bibliothèque - Bâtiment 34, campus de Gif


  • Mardi 12 juin 11:30-12:30 - Hong Wang

    Cytoskeleton club

    Résumé : Talin inhibits actin polymerization - Focal adhesions (FAs) play a major role in many physiological functions. Focal adhesions mechanically couple the extracellular matrix (ECM) to the dynamic and contractile actomyosin cytoskeleton, via transmembrane receptors of the integrin family and actin-binding proteins (ABPs). Among these ABPs, talin plays a major role, including activating integrins and anchoring cytoskeleton to FAs. Talin recruits the ABP vinculin in response to force which also associate to the ABP VASP. Although the ability of vinculin and VASP to regulate actin assembly is known, talin activity has never been studied. Our project is to understand the ability of the talin-vicnulin-VASP complex to regulate actin assembly. As preliminary step, we characterized talin activity. Talin contains three actin-binding domains (ABDs). ABD1 spans along the F2 and F3 subdomains of the FERM domain. ABD2 is located in the center of the rod. ABD3, is located at the C-terminus of the protein. Here we use kinetic assay of actin polymerization in fluorescence spectroscopy and actin filament observation in Total Internal Reflection Fluorescence Microscopy (TIRF) to study talin activity. The detail characterization of talin ABD1 demonstrates that it blocks actin filament barbed end elongation.

    Lieu : Bibliothèque - Bâtiment 34, Campus de Gif


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