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Home > Departments > Genome Biology > Daan NOORDERMEER : Chromatin Dynamics

Group Chromatin Dynamics

How does the organization of chromatin influence the activity of genes? The Chromatin Dynamics group studies this question by linking epigenetics and 3D DNA structure using systems biology approaches in four projects: (1) dynamics of DNA organization during the mammalian life cycle and in cancer, (2) 3D genome organization of epigenetic domains for gene regulation, (3) coordinated regulation of gene networks by epigenetic mechanisms and (4) variability of 3D genome organization within the cell population and its influence on single-cell gene expression.

Team Members

Team_2018

Daan Noordermeer – Team leader
Marine Beinat – Visiting scientist INRA
Sébastien Bloyer – Professor University Paris-Sud
Li-Hsin Chang – Post-doc
Joanne Edouard – Research Engineer
Sourav Ghosh - Post-doc
Mélanie Miranda – Research Engineer
Benoit Moindrot –
           Assistant professor University Paris-Sud
Laura Moniot Perron – PhD student
Julie Segueni - M2 student


Research projects

The Chromatin Dynamics Group started its operations in 2014. We study how the 3D structure of DNA regulates the activity of the genes in mammalian genomes. Particularly, we are interested in the regulatory functions of epigenetic mechanisms, insulator proteins and the 3D organization of the genome, and how these components act together. To answer these questions, we study mouse cells using a combination of (epi)genomics (ChIP-seq, Hi-C, 4C-seq), imaging (conventional and confocal fluorescent microscopy), bio-chemical approaches and bio-informatics.


Recent publications


- Llères, et al. (2019) CTCF controls imprinted gene activity at the mouse Dlk1-Dio3 and Igf2-H19 domains by modulating allele-specific sub-TAD structure. Genome Biology; 20:272. Link
- Shukron, et al. (2019) Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers. Nature Communications; 10:2626 Link
- Greenberg, et al. (2019) Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency. eLife; 8:e44057
Link
- Sobecki, et al. (2018) MadID, a versatile approach to map protein-DNA interactions, highlights telomere-nuclear envelope contact sites in human cells. Cell Reports; 25:2891-2903.
Link
- Vieux-Rochas, et al. (2015) Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain. PNAS; 112:4672-4677 Link


Key words

3D genome organization, Histone modifications, Insulator Proteins, Gene regulation, CTCF, TADs


Contact


NOORDERMEER Daan [Researcher - CNRS]
Chromatin Dynamics [Leader]
01 69 82 31 38 Gif - Bât 26

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