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Home > Departments > Genome Biology > Daniel GAUTHERET : RNA Sequence, Structure & Function

Daniel GAUTHERET : Group Presentation

RNAs form a widely diverse family of molecules that can store genetic information and control many aspects of cell life. Our laboratory seeks to improve understanding of the RNA world, from the origins of life to modern RNA functions in bacteria, plants and animals.

Project :

Our laboratory develops new bioinformatics and biochemichal technologies to gain insight into the evolution and mechanisms of RNA activities. Three lines of research are explored :

RNA discovery. Claire Toffano-Nioche and Daniel Gautheret develop bioinformatics tools for the discovery of new RNA genes in genome sequences. We compare genomic sequences of distant species or within human populations to find evidence of evolutionary constraints that are important clues revealing the presence of RNA genes. Alternatively, we use Next Generation Sequencing (NGS) technologies that can produce millions of RNA sequences from a living tissue to observe the activity of genomic regions that produce messenger or non-coding RNAs.

RNA structure and interactions. Fabrice Leclerc develops bioinformatics tools for the prediction of RNA-protein contacts in the three dimensional space. These programs also predict cognate RNAs for any given RNA-binding protein, which could be important for the design of new drugs.

RNA function and processing. Jean Lehmann is interested in the role played by RNA at the origin of the genetic code now used by all organisms. To this aim he develops new biochemical methodologies that enable the selection and identification of RNA molecules with decoding-related activities. He also analyzes RNA sequences and structures for new clues on regulatory RNA functions. Daniel Gautheret uses high-throughput transcriptome data to understand RNA-based regulations and the multiple processing steps that RNAs undergo after their synthesis.

Interactions between the elbow of a tRNA and a « double T-loop module » (bue+red element), a novel, recurrent RNA motif identified by Lehmann et al. The motif serves as a platorm for docking the tRNA elbow in ribosomal RNA (left, top), the RNAse P ribozyme (left, bottom) and the T-box riboswitch (right).

Key words :

RNA, non-coding RNA, regulatory RNA, RNA world, catalytic RNA, RNA-protein interactions, RNA processing, genome annotation, genetic code

Contact :

GAUTHERET Daniel [Professor - UPSaclay]
RNA Sequence, Structure & Function [Leader]
eBIO [Scientific Manager]
01 69 82 62 38 Orsay - Bât 400

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