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Biochemistry, Biophysics and Structural Biology Department

Director : Bruno Robert
Deputy directors : Sylvie Nessler & Françoise Ochsenbein
Executive assistant : Jocelyne Ergotte

Researchers from the Department of Biochemistry, Biophysics and Structural Biology are interested in protein architectures, and studying how their different structural levels and their interactions regulate their functions. They study soluble and membrane protein assemblies involved in major biological processes of eukaryotic and bacterial cells.
Studies performed in this department are based on the joint use of biochemical approaches, molecular biology and genetics, with the use of crystallography methods, advanced spectroscopy (NMR, optical, vibrational, magnetic ...) and modeling. This range of techniques helps understanding biological structures at different scales, from the atom to the multicellular organism. The study of protein structures at the atomic scale is used for example to determine how the structure of the active site of an enzyme allows it to perform its function. At the molecular and multi-molecular scales, determination of structures of proteins and protein domains helps describing the modes of interaction of active assemblies. At the cellular level, the study of the composition, structure and dynamics of different components that recruit large numbers of partners, leads to the understanding of the regulation of complex processes in vivo.

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