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Biochemistry, Biophysics and Structural Biology department

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  • Friday 28 February 14:00-15:00 - Volker LOHMANN - University of Heidelberg

    Shaping the lipid composition of viral replication organelles by Hepatitis C virus

    Résumé : Chronic Hepatitis C virus (HCV) infections affect 71 million people worldwide, often resulting in severe liver damage. Since 2014 highly efficient therapies based on direct acting antivirals (DAAs) are available, offering cure rates of almost 100%, if the infection is diagnosed in time. It took more than a decade to discover HCV in 1989 and another decade to establish the first cell culture model, which was essential for therapy development, from drug screening to understanding of mode of action and resistance. More recently we are beginning to understand the molecular basis for efficient HCV replication in cell culture, which is highly dependent on the shaping of the lipid composition of the membranous viral replication organelle, mediated by host factors like PI4KA and SEC14L2. This presentation will summarize our current knowledge on the mechanism of action of host factors contributing to HCV RNA synthesis and provide an outlook on future opportunities based on our increasing understanding of molecular mechanisms governing HCV replication.

    Lieu : Bibliothèque - Bâtiment 34, Campus de Gif-sur-Yvette

  • Thursday 2 April 14:00-15:30 - Dorit Hanein - Institut Pasteur, Paris

    Biochemistry, Biophysics and Structural Biology department

    Résumé : Invited by Julie Ménétrey

    Lieu : Auditorium I2BC - Building 21, Avenue de la Terrasse, Gif-sur-Yvette

  • Thursday 23 April 11:00-12:00 - Jacqueline CHERFILS - Ecole normale supérieure Paris-Saclay

    Regulation and inhibition of GTPase-membrane interactions

    Lieu : Salle Lederer - Bâtiment 430, Campus d’Orsay

  • Friday 24 April 11:00-12:00 - Daniel LEVY - UMR CNRS 168, Physico-Chimie Curie, Institut Curie, Paris

    Probing the coupling at large scale of proteins and membranes by cryo-EM and cryo-tomography

    Lieu : Auditorium I2BC - Bâtiment 21, Campus de Gif-sur-Yvette

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