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Département Biochimie, Biophysique et Biologie Structurale

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  • Vendredi 6 novembre 11:00-12:00 - Valérie Biou - Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, Institut de Biologie Physico-Chimique

    Energy supply of heme import in bacteria : Cryo-EM structures of two membrane complexes

    Résumé : Gram negative bacteria import iron from their host cells via a two-membrane spanning complex energised by a TonB-like complex in the inner membrane. We solved the structures of two partners of TonB from Serratia marcescens : ExbB pentamer and its complex with ExbD. The structures show the detailed location of the partners and exhibit differences with respect to the E. coli complex.

    Lieu : Amphithéatre de Neurospin, CEA Saclay -

  • Mardi 17 novembre 11:30-13:30 - Dorit Hanein - Institut Pasteur, Paris

    Coupling molecular activation and its functional output through 4d multiscale imaging - Correlative light and cryogenic cellular tomography studies

    Résumé :

    How do cells employ large, macromolecular machineries in cellular processes ?
    Despite of their key roles in every biological process and accumulated knowledge of composition and interactions, how nanomachine assemblies are organized in cells remains a mystery, and simplified schematic “cartoons” are currently our primary source of information. This is a knowledge gap given the importance in development, cancer biology, and tissue engineering. Specifically today, in which pathogens are taking hold on these machineries to promote their own survival, inflicting havoc on their unwilling host.
    I plan on presenting how we can move beyond “cartoon biology” and generate quantitative, (sub)nanometer-scale, three-dimensional structures of various molecular machineries in their native environment and in well-defined functional states. I will describe progress towards a technology platform that combines a unique set of state-of-the art light and cryogenic electron microscopy technologies, mechanical engineering, and protein expertise to provide a direct sub-nanometer scale definition on how these nano-machines structurally adapts to collectively response to changes in the environment, and thus provide clues on how to avert their malfunction in disease or infection. 
    Invited by Julie Ménétrey
    Due to Covid-19 there is a limited number of participants, please register here :

    Lieu : Auditorium I2BC

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