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Human mitochondrial translation : what makes the proteins and how are they escorted to their final destination ?

Vendredi 6 avril 2018 10:00-11:00 - Zofia CHRZANOWSKA LIGHTOWLERS - Newcastle University, invitée par N. Bonnefoy

Human mitochondrial translation : what makes the proteins and how are they escorted to their final destination ?

Résumé : The ribosome is the molecular machinery that synthesises proteins from template mRNA. Many features are common to ribosomes be they bacterial 70S particles, or 80S monosomes present in the eukaryotic cytosol. Although mitoribosomes have retained certain elements of the bacterial ribosome, both protein and rRNA, they have also diverged from the template in a number of ways. This is particularly true for human mitochondria that have been revealed by cryo-EM to have integrated unexpected components. These similarities, differences and some of the idiosyncrasies of the human mitoribosome will be described along with an example of the plasticity in the system, which is seen when things go wrong.

Lieu : Bibliothèque, Bât. 34 - Campus de Gif-sur-Yvette

Pour en savoir plus sur cet événement, consultez l'article Département Biologie Cellulaire