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  • Génomes

    • Lundi 24 septembre 11:00-12:00 - Jade Wang - Department of Bacteriology, University of Wisconsin at Madison, USA

      Spontaneous Mutations and Phenotypic Switches in the Bacterium Bacillus subtilis

      Résumé : The ability to generate diversity within a clonal population is important for organisms to survive later onset of selective pressures. For example, in bacteria, antibiotic resistance can arise via spontaneous mutagenesis, which is an example of a genotypic switch, and antibiotic tolerance can arise via persister formation, which is an example of a phenotypic switch. Characterization of both processes is challenged by the difficulty of detecting switched cells, which are rare events, within a large population.
      In this lecture, I will discuss ongoing efforts in my lab to characterize these two processes
      Contact : Frédéric BOCCARD <Frederic.BOCCARD>

      Lieu : Salle des séminaires- bâtiment 26 - Campus CNRS de Gif-sur-Yvette


    • Vendredi 28 septembre 11:00-12:00 - Joana Santos - Institute of Pharmacology and Structural Biology (IBPS), Toulouse

      How malaria parasites commit : a tale of transcription factors and epigenetics

      Résumé : Malaria, a disease that infects 3% of the world population and kills half a million people each year, is caused by the parasite Plasmodium. The disease symptoms are correlated with exponentially increasing waves of red blood cell (RBC) invasion and egress, in which parasite forms called schizonts rupture and release merozoites fit for a new round of RBC invasion. Alternatively, some schizonts (<10% of the population) enter the sexual pathway and differentiate into male and female gametocytes. While morphologically identical, sexually committed- and asexually committed-schizonts are transcriptionally programmed to either generate merozoites that invade RBCs, replicate and originate new merozoites, or that instead differentiate into gametocytes. Both ways are indispensable for parasite survival - Plasmodium must invade in order to subsist because it is an obligatory intracellular parasite, and gametocytes assure host-host transmission because they are the only parasite forms that can be uptake during a mosquito bite. How schizonts commit to each pathway remains a mystery.
      The Plasmodium genome is organized similarly to other eukaryotes and gene expression is regulated by binding of transcription factors (TFs) to promoter regions upstream of gene bodies. The ApiAP2 is the only characterized family of TFs in Plasmodium. I have characterized an essential ApiAP2 TF, named AP2-I, that regulates expression of the majority of invasion genes by binding to their promoters and recruiting a bromodomain protein (BDP1). Intriguingly, several lines of evidence suggest that AP2-I and BDP1 are not only involved in programming parasites to invade RBCs, but may also program parasites to enter the sexual development program. If this model were proven correct, these would be the first protein factors involved in schizont commitment.
      I propose to use different genomic and molecular approaches at the population and single cell level, including Cas9- and Cas13-derived methods as well as real time imaging, to identify the transcription regulation mechanisms involved in parasite commitment to the asexual and sexual pathways.
      Contact : Mireille Betermier <mireille.betermier>

      Lieu : Bibliothèque- bâtiment 34 - Campus CNRS de Gif-sur-Yvette


  • cytoskeleton club

    • Mardi 9 octobre 11:30-13:00 - Julien Pernier - Institut Curie, UMR CNRS 168 - A new actin depolymerase : a catch bond Myosin 1 motor

      Cytoskeleton club

      Lieu : Bibliothèque - bât. 34


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