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Séminaire

  • Génomes

    • Lundi 15 janvier 14:00-15:00 - Annabelle Decottignies - de Duve Institute, Brussels

      Revisiting cellular immortality in melanoma

      Résumé : Unlimited replicative potential is one of the hallmarks of cancer cells. In melanoma, hTERT (telomerase reverse transcriptase) is frequently overexpressed because of activating mutations in its promoter, suggesting that telomerase is necessary for melanoma development. We observed, however, that a subset of melanoma metastases and derived cell lines had no telomere maintenance mechanism. Early passages of the latter displayed long telomeres that progressively shortened and fused before cell death. We propose that, during melanoma formation, oncogenic mutations occur in precursor melanocytes with long telomeres, providing cells with sufficient replicative potential, thereby bypassing the need to re-activate telomerase. Our data further support the emerging idea that long telomeres promote melanoma formation. These observations are important when considering anticancer therapies targeting telomerase.
      Contact : Laure CRABBE <Laure.CRABBE i2bc.paris-saclay.fr>

      Lieu : Auditorium - bâtiment 21 - Campus CNRS de Gif-sur-Yvette

      Article

    • Vendredi 26 janvier 14:00-15:00 - Yaser Hashem - Institut Européen de Chimie et de Biologie, INSERM

      Protein translation initiation in eukaryotes : A jigsaw puzzle that has barely started yielding its picture

      Résumé : Translation initiation in eukaryotes is a highly regulated and rate-limiting process. It results in the assembly and disassembly of numerous transient and intermediate complexes involving over a dozen initiation factors (eIFs). This process culminates in the accommodation of a start-codon marking the beginning of an open reading frame (ORF) at the appropriate ribosomal site. Here, we present a model of the eukaryotic translation initiation process based on recent structures mainly derived by cryo-EM. In addition, we present new results that highlight some of the structural implications of the kozak sequence on the initiation complex formation. Finally we present some of the species-specific aspects of translation initiation in Kinetoplastids, a group of pathogenic eukaryotic organisms.
      Contact : Carmela Giglione <carmela.giglione i2bc.paris-saclay.fr>

      Lieu : Bibliothèque - bâtiment 34 - Campus CNRS de Gif-sur-Yvette

      Article

  • Biologie Cellulaire

    • Vendredi 12 janvier 11:00-12:30 - Cyril ZIPFEL - The Sainsbury Laboratory, Norwich, UK, invité par Grégory VERT

      Regulation of receptor kinase-mediated immune signaling

      Lieu : Auditorium - bâtiment 21 - Campus de Gif

      Article

    • Vendredi 19 janvier 11:00-12:30 - Andreu CASALI - IRB Barcelona, Spain, invité par Jacques Montagne

      Secondary tumor formation in Drosophila : a model for metastasis

      Lieu : Auditorium - bâtiment 21 - campus de Gif-sur-Yvette

      Article

  • cytoskeleton club

    • Mardi 9 janvier 11:30-12:30 - Audrey Esclatine

      Cytoskeleton club

      Résumé : A protein of Epstein-Barr-Virus perturbs mitochondrial dynamics by promoting mitochondrial fission followed by mitophagy

      Lieu : Bibliothèque - Bâtiment 34, campus de gif

      Article

Soutenance

  • Biologie Cellulaire

    • Vendredi 26 janvier 14:00-18:00 - Elsa Demes - Département de Biologie Cellulaire, I2BC

      Etude in vivo des variations de [NO3-] et de pH dans le compartiment cytosolique de cellules de garde et caractérisation fonctionnelle de deux transporteurs vacuolaires de type CLC chez Arabidopsis thaliana.

      Lieu : Auditorium I2BC - Bâtiment 21, Campus de Gif-sur-Yvette

      Article

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