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  • Génomes

    • Vendredi 29 mars 2019 11:00-12:00 - Claude Bruand - Laboratoire des Interactions Plantes-Microorganismes (LIPM), Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France

      Non-homologous end-joining in bacteria : from DNA double-strand break repair to acquisition of heterologous DNA

      Résumé : DNA double-strand breaks (DSB) in bacteria can be repaired either by homologous recombination dependent on the universal RecA protein, or by non-homologous end-joining (NHEJ), a two-component system relying on the Ku and LigD proteins, present in 20 % of bacterial species. Strikingly, Sinorhizobium meliloti encodes several potential Ku and LigD proteins, which prompted us to perform a comprehensive genetic analysis of NHEJ in this bacterial species. We report here the results of this study, which brings new insights into the mechanism, regulation and putative function of NHEJ in bacteria.
      Dupuy P., Sauviac L. and Bruand C. (2018) Stress-inducible NHEJ in bacteria : function in DNA repair and acquisition of heterologous DNA. Nucleic Acids Res. doi : 10.1093/nar/gky1212.
      Bertrand C., Thibessard A., Bruand C., Lecointe F., Leblond P. (2019) NHEJ in bacteria : a never ending story. Mol Microbiol. doi : 10.1111/mmi.14218
      Contact : Julien Bischerour and Mireille Bétermier

      Lieu : Salle des séminaires- bâtiment 26 - Campus CNRS de Gif-sur-Yvette


  • Biologie Cellulaire

    • Vendredi 1er mars 2019 11:30-12:30 - Valérie Legué - Université Clermont-Auvergne, UMR INRA/UCA PIAF

      The root cap shape is a key feature in the response of the increase in medium strength

      Lieu : Salle Bibliothèque - bâtiment 34 - Campus de Gif


  • I2BC

    • Jeudi 21 mars 2019 14:00-15:00 - Tom Owen-Hughes - School of Life Sciences, University of Dundee

      Structure and function of chromatin remodelling ATPase’s and their dysfunction in human disease

      Résumé : The genomes of eukaryotes are associated with histone proteins to form a DNA protein complex called chromatin. The regulation of chromatin structure provides one means by which eukaryotic organisms regulated access to DNA. One means by which this is achieved involves the action of an extended family molecular motor proteins, known as chromatin remodelling ATPases. Advances to electron microscopy provide an opportunity to gain major new insights into how these motor proteins interact with chromatin. Our ongoing work providing insight into how these molecular machines reconfigure nucleosomes will be presented. It has become apparent that the genes that encode these motor proteins, and additional subunits of the multi-subunit complexes they are found in, are often genetically altered in cancers of different tissues and a number of neurological disorders. This means it is important to determine how loss of these enzymes affects chromatin structure and gene regulation. With this aim we have established targeted degrons characterise the consequences of removing different enzyme subunits over time. The ongoing characterisation of these changes will be presented.

      Lieu : Auditorium I2BC - Bât. 21, Campus de Gif-sur-Yvette

      Notes de dernières minutes : ATTENTION DATE ET HEURE MODIFIEES


  • cytoskeleton club

    • Mardi 12 mars 2019 11:30-12:30 -

      Cytoskeleton club - Internal seminar

      Lieu : Bibliothèque - bât. 34


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