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  • Génomes

    • Vendredi 5 avril 11:00-12:00 - Charles Dorman - Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Ireland

      Bacterial decision-making

      Résumé : The model organism Escherichia coli inhabits a series of environments that impose on the bacterium a need to be nimble in making adjustments to its composition and physiology if it is to survive and thrive. E. coli provides a good experimental system for understanding how bacteria in general interpret their surroundings and make appropriate responses to change, a process that can be described as decision making. Decisions are made at the level of individual cells but are made manifest at the level of the whole bacterial population. In this lecture the dynamic structure of the E. coli nucleoid will be compared to the workings of a primitive brain and adjustments to the 4-dimensional structure of the nucleoid will be considered in terms of their impact on the operation of a genetic switch that governs the composition of the bacterial cell surface and the ability of the individual bacterium to adhere to surfaces in the animal or human host or in the external environment. Finally, the implications of this decision-making process will be considered for the creation of physiological diversity within a genetically homogenous bacterial population and for influencing the reversible commitment to either an independent (planktonic) style of living or to a community-based strategy within a biofilm.

      Lieu : Bibliothèque Bât. 34 - Campus de Gif-sur-Yvette

      Notes de dernières minutes : The Chair of Microbiology at Trinity College Dublin was established 100 years ago (in 1919) as the Chair of Bacteriology and Preventive Medicine. Charles Dorman has held this chair for the past 25 years. He is a Member of the Royal Irish Academy, a Fellow of the American Academy of Microbiology, a Fellow of the Royal Society of Biology, a founding member of the European Academy of Microbiology, a Trustee of the Microbiology Society (London) and a Science Foundation Ireland Principal Investigator. Professor Dorman has published over 200 articles on the topic of bacterial gene regulation.

      Article

  • Biologie Cellulaire

    • Vendredi 12 avril 11:30-12:30 - Anne LOMBES - Institut Cochin, Paris

      Mitochondrial diseases : from bedside to bench and return...

      Résumé : Mitochondrial diseases are rare diseases due to defective oxidative phosphorylation pathway. From first identification to treatment, these diseases pose innumerable problems in clinical practice that led to important developments in investigation methodology. On the other hand, the better these diseases are known, the further they demonstrate the complexity of their underlying mechanisms : from transmission of heteroplasmic mitochondrial DNA mutation, to tissue specific impact or most efficient (but unknown) compensatory mechanisms. As such, mitochondrial diseases are prone to induce numerous travels from bedside to bench and return.... Some of which will be described during the talk.

      Lieu : Bibliothèque - bâtiment 34 - campus de Gif-sur-Yvette

      Article

  • Virologie

    • Vendredi 19 avril 11:00-12:30 - Gregory Moseley - Department of Microbiology Biomedicine Discovery Institute, Monash University Clayton Campus, Victoria 3800 Australia

      Viral hijacking of the Host DNA damage and Innate Immune Responses : Novel Disease Mechanisms and Therapeutic Targets

      Résumé : Despite a limited coding capacity, RNA viruses such as rabies (RABV) and Nipah (NiV) virus can arrest potent control over host cell biology, and are often highly lethal. Central to this are multifunctional viral proteins that can modulate critical cellular processes, in addition to mediating conserved roles in replication.
      My laboratory seeks to delineate these functions to understand how viruses subvert cell biology, and thereby identify new targets to develop vaccines and antivirals.
      I will discuss our recent progress on Henipaviruses and lyssaviruses, including new findings on viral targeting of the nucleolus and unexpected roles in modulating the DNA-damage response to control the host cell1. I will also discuss new data on viral antagonism of immunity2, and how this is informing potential methods to block viral immune evasion for vaccine/therapeutic approaches, as well as revealing fundamental mechanisms whereby viral proteins can ‘multi-task’ in coupling immune evasion and genome replication.
      1 Nat Commun. 2018 ; 9(1):3057 ; J Virol. 2015 ; 89(3):1939
      2 Biomol NMR Assign. 2018. doi : 10.1007/s12104-018-9841-4 ; Sci Rep. 2016 ; 6:33493 ; J Infect Dis. 2014 ;209(11):1744

      Lieu : Salle des séminaires - Bât. 14C, Campus de Gif-sur-Yvette
      Contact : Danielle Blondel

      Article

  • cytoskeleton club

    • Mardi 9 avril 11:30-12:30 -

      Cytoskeleton club - Internal seminar

      Lieu : Bibliothèque - bât. 34

      Article

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