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  • Microbiologie

    • Mardi 17 décembre 11:30-12:30 - Kevin WALDRON - Newcastle University, UK

      Bacterial copper detoxification and storage at the host-pathogen interface

      Résumé : Copper is an essential micronutrient for bacteria, but is highly toxic in excess, resulting in the evolution of complex copper homeostasis networks in bacteria that regulate the acquisition, detoxification and utilisation of this metal ion nutrient. The mammalian immune system exploits copper toxicity, employing copper in its arsenal of antibacterial weapons, and copper is an appealing antibacterial material for medical and technological applications. The Waldron lab is studying the molecular mechanisms and evolution of conserved components of the bacterial copper homeostasis systems of both Gram positive and Gram negative bacterial pathogens. Data will be presented demonstrating (i) how copper toxicity affects central carbon metabolism, (ii) how the spread of copper resistance genes is influencing the evolution of pathogens, and (iii) an unanticipated role for copper storage proteins in the bacterial defence against immune attack.

      Lieu : Salle Kalogeropoulos - Bâtiment 400, Campus d’Orsay


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