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20 juin 2017: 1 événement

  • Evènements I2BC

    Mardi 20 juin 2017 11:00-12:00 - Dr Huy Bui - Department of Anatomy and Cell Biology, McGill University, Montreal, Canada

    High-resolution structure of the doublet microtubule reveals new classes of microtubule- associated proteins and insights into its assembly mechanism

    Résumé : Cilia are ubiquitous, hair-like appendages found in eukaryotic cells that carry out functions of cell motility and sensory reception. Cilia contain an intriguing cytoskeletal structure, termed the axoneme, that consists of nine doublet microtubules radially interlinked and longitudinally organized in multiple specific repeat units. Little is known, however, how the axoneme allows cilia to be both actively bendable and sturdy or how it is assembled. To answer these questions, we used cryo-electron microscopy to structurally analyze several of the repeating units of the doublet at subnanometer resolution. This structural detail enables us to unambiguously assign α- and β-tubulins in the doublet microtubule lattice. Our study, for the first time, demonstrates the existence of an inner sheath composed of different kinds of microtubule inner proteins inside the doublet that likely stabilizes the structure and facilitates the specific building of the B-tubule.
    Invité par Anne-Marie Tassin, équipe Biogénese et fonction des structures centriolaires et ciliaires

    Lieu : Auditorium - Bâtiment 21, campus de gif

    En savoir plus : Evènements I2BC