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8 septembre 2017: 1 événement

  • Département Biologie des Génomes

    Vendredi 8 septembre 2017 11:00-12:00 - Dr Diarmaid Hughes - Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

    Evolutionary trajectories to ciprofloxacin-resistance in Escherichia coli

    Résumé : Ciprofloxacin is an important antibacterial drug targeting Type II topoisomerases, and is highly active against Gram-negatives including Escherichia coli. The evolution of resistance to ciprofloxacin in E. coli always requires multiple genetic changes, usually including mutations affecting two different drug target genes, gyrA and parC, but frequently also involving mutations in drug-efflux regulators. Resistant mutants selected in vitro or in vivo can have many different mutations in target genes and efflux regulator genes that contribute to resistance. However, among resistant clinical isolates there are a few predominant genotypes, suggesting they have a selective advantage. By combining experimental data and mathematical modeling, we mapped the fitness landscape that constrains the evolutionary trajectories taken during the development of clinical resistance and could explain the predominance of the most frequently selected genotypes.
    Contact : Nara Figueroa

    Lieu : Auditorium - Bâtiment 21, campus de Gif

    En savoir plus : Département Biologie des Génomes