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7 mars 2018: 1 événement

  • Evènements I2BC

    Mercredi 7 mars 11:00-12:30 - Rati Fotedar - Sanford Burnham Prebys Medical Discovery Institute, San Diego, California, USA

    Braking the cell cycle : some twists and turns

    Résumé : Our contributions to the mammalian cell cycle and DNA damage fields have defined the role and mechanisms of protein modification and protein degradation in regulation of the cell cycle, DNA replication and DNA damage/repair. We have focused on proteins regulating the cell cycle (CDKs, Rb, Emi1), DNA replication (RPA, RFC, PCNA), DNA damage checkpoint (p53, p21, Emi1, WISp39, Hsp90, APC), DNA repair pathways (NER, MMR), mitosis (APC) and stress signaling (MAPK, mTOR). Our work has provided insights into the biochemical and molecular framework of DNA damage signaling by the p53 tumor suppressor as well as the role of Hsp90 and of an E3 ubiquitin ligase in this process. Cell cycle regulation is crucial for normal development, for differentiation and for tumorigenesis. I will describe recent work in which we identified a previously unknown mechanism of how CDKs regulate cell cycle progression. Finally, while cell cycle arrest is required for senescence, it is not sufficient by itself to induce this state. Our recent work reveals signals that act downstream of cell cycle arrest to induce senescence.

    Invité par Thierry Meinnel

    Lieu : Auditorium I2BC - Bâtiment 21
    Campus de Gif-sur-Yvette

    En savoir plus : Evènements I2BC