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30 mars 2018: 3 événements

  • Département Biologie Cellulaire

    Vendredi 30 mars 11:00-12:00 - Manuel THERY - Institut Universitaire d'Hematologie, Hopital Saint Louis, Paris, invité par A.M. Tassin

    Making sense of symmetry breaks

    Résumé : In this presentation I will discuss the role of friction in and on actin and microtubule networks. I will describe few examples showing that friction in the networks tend to maintain the symmetry whereas friction on the networks tend to break it. I will discuss how these geometrical rules propagate to the overall cell polarity via actin-microtubule crosstalk.

    Lieu : Bibliothèque - bâtiment 34 - Campus de Gif-sur-yvette

    En savoir plus : Département Biologie Cellulaire
  • Département Biochimie, Biophysique et Biologie Structurale

    Vendredi 30 mars 11:00-12:30 - Ludovic Sauguet - Institut Pasteur, Unité de Dynamique Structurale des Macromolécules

    Secret from the abyss : crystal and cryo-EM structures of the D-family DNA polymerase (PolD) reveal that DNA replication and DNA transcription share a joint evolutionary history in archaea

    Résumé : Archaeal replicative DNA polymerases D (PolD) constitute an atypical class of DNA polymerases. Crystal and Cryo-EM structures of Pyrococcus abyssi PolD reveal a catalytic core strikingly different from all other known DNA polymerases. Rather, the PolD catalytic core has the same “double-psi b-barrel” architecture seen in the RNA polymerase (RNAP) superfamily, which includes multi-subunit transcriptases of all domains of life. This finding bridges together, for the first time in cellular life, DNA transcription and DNA replication within the same protein superfamily.

    En raison des conditions d’accès sur le Centre d’Etudes de Saclay, les personnes qui désirent assister à ces conférences sont invitées à contacter Jean-Baptiste Charbonnier (Tél. : 01 69 08 76 77) au moins 3 jours avant la date de la conférence pour les citoyens de l’Union Européenne ou au moins 20 jours pour les citoyens hors Union Européenne. A la porte Nord (accès par la D36), ces personnes devront présenter une pièce d’identité prouvant leur nationalité et devront préciser qu’elles viennent assister à un séminaire du SB2SM/LBSR.
    Due to the restricted access to the Centre d’Etudes de Saclay, scientists who wish to attend these seminars should call Jean-Baptiste Charbonnier (Tel : 01 69 08 76 77) at least 3 days before the date of the conference for EU citizens or at least 20 days for non-EU citizens. At the North entrance (D36 road), these scientists will have to present a passport to prove their nationality and state that they will attend the seminar of the SB2SM/LBSR.

    Lieu : Salle de conférence du Bat 144, CEA, CE-Saclay. - I2BC, Site Saclay

    En savoir plus : Département Biochimie, Biophysique et Biologie Structurale
  • Département Biologie des Génomes

    Vendredi 30 mars 14:00-15:00 - Gisou Van der Goot - Ecole Polytechnique Fédérale de Lausanne

    Function and dynamics of protein palmitoylation

    Résumé : Protein function can be regulated by a variety of post-translational modifications. One that is of particular interest, but still poorly understood due to the technical difficulties in studying it, is S-acylation, the only reversible lipid modification of proteins. Over recent years it has become apparent that 10% or more of the human proteome can undergo this modification. It is mediated by polytopic transmembrane enzymes of the DHHC family of which human have 23, flies and worms about 20. Mutations in these enzymes have been associated with higher brain function disorders and cancer. Removal of the acyl chain occurs through the action of Acyl Protein thioesterases, of which so far 5 have been identified.
    The presentation will be focused on palmitoylation in the endoplasmic reticulum, where a variety of key functions are regulated by palmitoylation. I will describe how the architecture of the compartment is controlled by palmitoylation via the ZDHHC6 palmitoyltransferase. This indicates that the activity of this enzyme needs to be tightly regulated. I will show that it is in fact controlled by a cascade of palmitoylation, reminiscent of the cascades observed in phosphorylation and ubiquitination.
    Contact : Carmela GIGLIONE <carmela.giglione>

    Lieu : Bibliothèque- bâtiment 34 - Campus CNRS de Gif-sur-Yvette

    En savoir plus : Département Biologie des Génomes