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22 mai 2018: 1 événement

  • Evènements I2BC

    Mardi 22 mai 11:00-12:00 - Eric Espagne - Département Biologie des Génomes, I2BC

    Meiotic recombination and pairing

    Résumé : Meiosis is the specialized cellular program by which a diploid germline cell gives rise to haploid gametes for reproduction. Its successful execution includes recognition and pairing of homologous maternal and paternal chromosomes (homologs) and establishment of inter-homolog recombinational interactions (crossover/chiasmata) that create the physical linkages required for their correct segregation. Errors in segregation lead to extra or missing chromosomes in gametes (aneuploïdy), a major cause of human pregnancy failure and congenital disorders as well as sterility in plants. To understand the origin of aneuploïdies, we use the power of the fungus Sordaria for meiotic analysis by merging molecular, genetic and single cell direct visualization of chromosomes.
    Biochemical events of crossover (CO) formation occur in physical and functional linkage with chromosome axial structure from initiation through post-CO chiasma development. To understand this linkage, we developed two main approaches : (1) Investigation of the complex program of interactions between homologs that results in CO formation and installation of the specific pairing structure called « synaptonemal complex » (SC). (2) Analysis of why a CO event at one position on the chromosome hinders the occurrence of another CO nearby. This interesting “interference” process (Muller, 1906) requires communication along the chromosomes but its implementation and its evolutionary rationale remain unclear.

    Lieu : Auditorium I2BC - Bâtiment 21 - Campus Gif-sur-Yvette

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