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29 mai 2018: 1 événement

  • Département Microbiologie

    Mardi 29 mai 2018 11:30-12:30 - Dr. Olivier Berteau - MICALIS, INRA, Jouys-en-Josas

    Radical SAM enzymes : Radically new reactions in natural product biosynthesis

    Résumé : Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large and diverse family of natural products. They possess interesting biological properties such as antibiotic or anticancer activities, making them attractive for therapeutic applications. RiPPs are produced according to a simple biosynthetic logic, a precursor peptide containing a leader (or a follower) sequence is synthesized and modified to various extents by tailoring enzymes. The modified peptide is then generally secreted and the leader (or follower) cleaved off. RiPPs have been shown to contain a wealth of post-translational modifications such as thioether bonds, unusual methylations or epimerizations. In a unique manner, the so-called radical SAM enzymes, an emerging superfamily of metallo-enzymes have been shown to catalyze all these various and chemically unrelated modifications. I will present recent advances in our understanding of radical SAM enzymes and the post-translational modifications they catalyze.

    Lieu : Salle Kalogeropoulos, Bât 400, Université Paris sud - Campus Orsay

    En savoir plus : Département Microbiologie