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9 novembre 2018: 1 événement

  • Département Biologie des Génomes

    Vendredi 9 novembre 14:00-15:00 - Michael Holdsworth - University of Nottingham, UK

    When the beginning determines the end : The role of the N-end rule pathway in plant growth and development

    Résumé : Abstract
    The N-end rule pathway represents an ancient conserved component of the Ubiquitin Proteasome System, that also has profound effects on proteostasis. It relates the identity of the amino terminal (Nt-) residue of a protein to its destruction by the UPS. Our recent work uncovered the simple biochemical mechanism that plants use to simultaneously sense oxygen and nitric oxide (NO), through the Cys-Arg/N-end rule pathway [1,2]. The AP2-domain ERFVII transcription factors are the first identified plant substrates of this pathway, with conditional stability based on the oxidation status of amino-terminal Cys, providing a homeostatic response mechanism to changes in oxygen and NO levels. This mechanism is used by plants to measure important ecological cues to protect the stem cell niche and enhance survival [3,4]. I will discuss our current approaches to understand N-end rule pathway regulated plant growth and development.
    Selected recent references
    1. Gibbs et al Nature 2011
    2. Gibbs et al Molecular Cell 2014
    3. Abbas et al Current Biology 2015,
    4. Vicente et al Current Biology 2017
    Contact : GIGLIONE Carmela <carmela.giglione i2bc.paris-saclay.fr>

    Lieu : Bibliothèque- bâtiment 34 - Campus CNRS de Gif-sur-Yvette

    En savoir plus : Département Biologie des Génomes

9 novembre 2018: 1 événement